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Showing 1–7 of 7 results
Advanced filters: Author: Marscha Hirschi Clear advanced filters

  • The anti-CRISPR protein IF9 (AcrIF9) specifically inhibits the type I-F CRISPR adaptive immune system. Here, the authors present the cryo-EM structure of AcrIF9 in complex with the type I-F CRISPR RNA-guided surveillance complex (Csy) and a dsDNA bound Csy-AcrIF9 structure, and find that AcrIF9 binding to the Csy complex triggers non-sequence specific dsDNA binding to Csy-AcrIF9, which might sequester the complex from its target DNA.

    • Marscha Hirschi
    • Wang-Ting Lu
    • Blake Wiedenheft
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-6

  • Development of a paralog-hopping approach leveraging chemical proteomic data on covalently liganded cysteines revealed an allosteric pocket shared by cysteine-containing and cysteine-less paralogous cyclin E proteins.

    • Yuanjin Zhang
    • Zhonglin Liu
    • Benjamin F. Cravatt
    Research
    Nature Chemical Biology
    Volume: 21, P: 420-431

  • Aminoacyl-tRNA synthetases catalyze the ligation of amino acids to their cognate tRNAs. Here the authors report the cryo-EM structure of a human mitochondrial seryl-tRNA synthetase•mtRNASer complex showing how strong mutation pressure on mtRNA genes drove a rewiring of intermolecular recognition rules.

    • Bernhard Kuhle
    • Marscha Hirschi
    • Paul Schimmel
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • Mitochondrial tRNAs are indispensable and yet underwent an extreme mutational erosion. The authors report the structures of a mitochondrial aaRS-tRNA complex and show how the most degenerated of all human mtRNAs is recognized by its cognate synthetase to maintain mitochondrial gene expression.

    • Bernhard Kuhle
    • Marscha Hirschi
    • Paul Schimmel
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • Transient receptor potential vanilloid channel 3 (TRPV3) responds to temperature and sensitizes upon repeated stimulation with either heat or agonists. Here authors present the cryo-EM structures of apo and sensitized human TRPV3 and describe the structural basis of sensitization.

    • Lejla Zubcevic
    • Mark A. Herzik Jr.
    • Seok-Yong Lee
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12