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Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway

Christopher L Karp
Leah M Flick
Nicos A Petasis
Research21 Mar 2004
Nature Immunology

Volume: 5, P: 388-392
Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma

Greater production of interleukin 17A is associated with severe asthma. Wills-Karp and colleagues show that the complement anaphylatoxins C3a and C5a have opposing roles in enhancing or suppressing IL-17a in allergic asthma.

Stephane Lajoie
Ian P Lewkowich
Marsha Wills-Karp
Research29 Aug 2010
Nature Immunology

Volume: 11, P: 928-935
Innate lymphoid cells wield a double-edged sword

Type 2 cytokine–producing innate lymphoid cells are present in human and mouse lungs, where they contribute to both type 2 immune responses and tissue repair.

Marsha Wills-Karp
Fred D Finkelman
News & Views19 Oct 2011
Nature Immunology

Volume: 12, P: 1025-1027
Regulation of angiogenesis by a non-canonical Wnt–Flt1 pathway in myeloid cells

James A. Stefater III
Ian Lewkowich
Richard A. Lang
Research29 May 2011
Nature

Volume: 474, P: 511-515
Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein

The common dust mite allergen Der p 2 is shown to replace MD-2 as the lipopolysaccharide-binding component and facilitates signalling through TLR4. It is suggested that Der p 2 tends to be targeted by adaptive immune responses because of its auto-adjuvant properties.

Aurelien Trompette
Senad Divanovic
Christopher L. Karp
Research07 Dec 2008
Nature

Volume: 457, P: 585-588
The germless theory of allergic disease: revisiting the hygiene hypothesis

Marsha Wills-Karp
Joanna Santeliz
Christopher L. Karp
Reviews01 Oct 2001
Nature Reviews Immunology

Volume: 1, P: 69-75
Time to draw breath: asthma-susceptibility genes are identified

Marsha Wills-Karp
Susan L. Ewart
Reviews01 May 2004
Nature Reviews Genetics

Volume: 5, P: 376-387
I-Tim-izing the pathways of counter-regulation

Tim-3, a member of the T cell immunoglobulin mucin family, is expressed by T_H1 cells. Analysis of Tim-3–Tim3 ligand signaling now shows this pathway is intimately involved in the counter-regulation of T helper type 1 immune responses.

Marsha Wills-Karp
Yasmine Belkaid
Christopher L Karp
News & Views01 Nov 2003
Nature Immunology

Volume: 4, P: 1050-1052
Serum amyloid A is a soluble pattern recognition receptor that drives type 2 immunity

Smole and colleagues show that the soluble pattern recognition receptor serum amyloid A (SAA) recognizes several mite allergenic proteins, including Der p 13 and Blo t 13, which are conserved fatty acid-binding proteins. Such FABP–SAA1 binding triggers epithelial cell release of the type-2-promoting cytokine IL-33, which in turn drives IL-13 production and allergic syptoms.

Ursula Smole
Naina Gour
Marsha Wills-Karp
Research22 Jun 2020
Nature Immunology

Volume: 21, P: 756-765
Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma

Christopher L. Karp
Andrew Grupe
Marsha Wills-Karp
Research01 Sept 2000
Nature Immunology

Volume: 1, P: 221-226
Asthma genetics: not for the TIMid?

A new family of conserved genes encodes mucin-like glycoproteins. These genes contribute to asthma susceptibility by influencing T_H differentiation and cytokine production.

Marsha Wills-Karp
News & Views01 Dec 2001
Nature Immunology

Volume: 2, P: 1095-1096
Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease

Cystic fibrosis is more severe in some individuals than in others. This study identifies the neutrophil transcriptional co-regulator IFRD1 as a new genetic modifier.

YuanYuan Gu
Isaac T. W. Harley
Christopher L. Karp
Research25 Feb 2009
Nature

Volume: 458, P: 1039-1042
Caffeine Modulates TNF-α Production by Cord Blood Monocytes: The Role of Adenosine Receptors

Raul Chavez-Valdez
Marsha Wills-Karp
Estelle B Gauda
Research01 Feb 2009
Pediatric Research

Volume: 65, P: 203-208
Mechanisms of modulation of cytokine release by human cord blood monocytes exposed to high concentrations of caffeine

Raul Chavez-Valdez
Rajni Ahlawat
Estelle B. Gauda
Research16 Mar 2016
Pediatric Research

Volume: 80, P: 101-109
C3a is required for ILC2 function in allergic airway inflammation

Naina Gour
Ursula Smole
Stephane Lajoie
Research13 Aug 2018
Mucosal Immunology

Volume: 11, P: 1653-1662
Nrf2 regulates gene-environment interactions in an animal model of intrauterine inflammation: Implications for preterm birth and prematurity

Thomas E. Sussan
Kuladeep Sudini
Shyam Biswal
ResearchOpen Access10 Jan 2017
Scientific Reports

Volume: 7, P: 1-9

Search

Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway

Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma

Innate lymphoid cells wield a double-edged sword

Regulation of angiogenesis by a non-canonical Wnt–Flt1 pathway in myeloid cells

Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein

The germless theory of allergic disease: revisiting the hygiene hypothesis

Time to draw breath: asthma-susceptibility genes are identified

I-Tim-izing the pathways of counter-regulation

Serum amyloid A is a soluble pattern recognition receptor that drives type 2 immunity

Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma

Asthma genetics: not for the TIMid?

Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease

Caffeine Modulates TNF-α Production by Cord Blood Monocytes: The Role of Adenosine Receptors

Mechanisms of modulation of cytokine release by human cord blood monocytes exposed to high concentrations of caffeine

C3a is required for ILC2 function in allergic airway inflammation

Nrf2 regulates gene-environment interactions in an animal model of intrauterine inflammation: Implications for preterm birth and prematurity

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