Nature Search

Observation of gradual brightening of P Cygni due to stellar evolution

Mart J. H. de Groot
Henny J. G. L. M. Lamers
Research30 Jan 1992
Nature

Volume: 355, P: 422-423
SARS-CoV-2 is transmitted via contact and via the air between ferrets

SARS-CoV-2 has rapidly spread globally and animal models to study transmission are needed. Here, Richard et al. show efficient transmission of SARS-CoV-2 between ferrets via direct contact and via the air, through respiratory droplets and/or aerosols.

Mathilde Richard
Adinda Kok
Sander Herfst
ResearchOpen Access08 Jul 2020
Nature Communications

Volume: 11, P: 1-6
Low levels of monkeypox virus-neutralizing antibodies after MVA-BN vaccination in healthy individuals

Historic smallpox vaccination and monkeypox virus (MPXV) infection elicit MPXV-neutralizing antibodies, but MPXV-neutralizing antibodies are less frequent and of lower magnitude after vaccination with MVA-BN—the vaccine approved and in use for protection against MPXV and smallpox.

Luca M. Zaeck
Mart M. Lamers
Rory D. de Vries
ResearchOpen Access18 Oct 2022
Nature Medicine

Volume: 29, P: 270-278
A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses

Rapid identification of host genes essential for virus replication may expedite the generation of therapeutic interventions. Here the authors generate mutant clonal intestinal organoids for 19 host genes previously implicated in coronavirus biology and identify the cell surface protease TMPRSS2 as a potential therapeutic target.

Joep Beumer
Maarten H. Geurts
Hans Clevers
ResearchOpen Access17 Sept 2021
Nature Communications

Volume: 12, P: 1-12
Filamentous fungus-produced human monoclonal antibody provides protection against SARS-CoV-2 in hamster and non-human primate models

The filamentous fungus expression system Thermothelomyces heterothallica (C1) is a protein expression system that may be useful for large scale antibody production. Here the authors characterise the production of a human monoclonal antibody that neutralises SARS-CoV-2 and compare functional properties in vitro and in animal models to antibodies produced using other methods.

Franziska K. Kaiser
Mariana Gonzalez Hernandez
Albert D.M.E. Osterhaus
ResearchOpen Access14 Mar 2024
Nature Communications

Volume: 15, P: 1-14
SARS-CoV-2 Omicron variant causes mild pathology in the upper and lower respiratory tract of hamsters

Since the emergence of SARS-CoV-2 several variants of concerns have been identified, with altered disease progression and transmission dynamics. Here, Armando et al. compare virus spread and pathology in the upper and lower respiratory tracts of Syrian golden hamster after 4 days post infection for VOCs Gamma, Delta and Omicron and find milder pathology for Omicron.

Federico Armando
Georg Beythien
Wolfgang Baumgärtner
ResearchOpen Access20 Jun 2022
Nature Communications

Volume: 13, P: 1-15
Duration and key determinants of infectious virus shedding in hospitalized patients with coronavirus disease-2019 (COVID-19)

Duration of infectious SARS-CoV-2 shedding is an important measure for improved disease control. Here, the authors use virus cultures of respiratory tract samples from COVID-19 patients and observe a median shedding duration of 8 days and a drop below 5% after 15,2 days post onset of symptoms.

Jeroen J. A. van Kampen
David A. M. C. van de Vijver
Annemiek A. van der Eijk
ResearchOpen Access11 Jan 2021
Nature Communications

Volume: 12, P: 1-6
Development of immunohistochemistry and in situ hybridisation for the detection of SARS-CoV and SARS-CoV-2 in formalin-fixed paraffin-embedded specimens

Fabian Z. X. Lean
Mart M. Lamers
Alejandro Nuñez
ResearchOpen Access14 Dec 2020
Scientific Reports

Volume: 10, P: 1-9
SARS-CoV-2 pathogenesis

In this Review, Lamers and Haagmans explore recent clinical and experimental advances in understanding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesis, interactions with host cells and the involvement of the immune system in the development of severe disease. Specifically, they focus on mechanisms underlying the development of COVID-19-associated acute respiratory distress syndrome.

Mart M. Lamers
Bart L. Haagmans
Reviews30 Mar 2022
Nature Reviews Microbiology

Volume: 20, P: 270-284
Resistance to SARS-CoV-2 infection in camelid nasal organoids is associated with lack of ACE2 expression

Tim I. Breugem
Samra Riesebosch
Bart L. Haagmans
ResearchOpen Access02 Sept 2024
npj Viruses

Volume: 2, P: 1-8
Mpox virus infects and injures human kidney organoids, but responding to antiviral treatment

Pengfei Li
Zhaoyu Du
Qiuwei Pan
CorrespondenceOpen Access03 Apr 2023
Cell Discovery

Volume: 9, P: 1-4
SARS-CoV-2 Omicron variant is highly sensitive to molnupiravir, nirmatrelvir, and the combination

Pengfei Li
Yining Wang
Qiuwei Pan
CorrespondenceOpen Access20 Jan 2022
Cell Research

Volume: 32, P: 322-324
Organoids in virology

Julie T. S. Chu
Mart M. Lamers
ReviewsOpen Access07 Feb 2024
npj Viruses

Volume: 2, P: 1-10

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