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Showing 1–6 of 6 results
Advanced filters: Author: Martijn Gloerich Clear advanced filters

  • Cell–cell adhesion and oriented cell division play key roles in tissue architecture, but how they are coordinated is not known. Here, the authors show that E-cadherin interacts with LGN, and thereby provides a cortical cue that serves to stabilize cortical attachment of astral microtubules at cell–cell adhesions, thus orienting the mitotic spindle.

    • Martijn Gloerich
    • Julie M. Bianchini
    • W. James Nelson
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11

  • Intestinal tuft cell subtypes represent successive stages of differentiation that is driven by crypt-villus signaling gradients. Here, the authors show that applying these gradients to organoids generates mature immune-related chemosensory tuft cells suitable for experimental studies.

    • Julian R. Buissant des Amorie
    • Max A. Betjes
    • Hugo J. G. Snippert
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • Microvilli are essential for the function of intestinal cells. Bos and colleagues have found that the polarity kinase LKB-1 induces PtdIns(4,5)P2 enrichment at the apical membrane. This leads to the successive accumulation of phosphatidic acid and the small GTPase Rap2A with its GEF and its effectors. These, in turn, trigger the changes in the actin cytoskeleton responsible for microvilli formation.

    • Martijn Gloerich
    • Jean Paul ten Klooster
    • Johannes L. Bos
    Research
    Nature Cell Biology
    Volume: 14, P: 793-801

  • Aligned collagen I is associated with the emergence of leader cells that are responsible for collective invasion. Here, the authors show that Collagen I and Yap signalling are in a feed-forward loop to drive the collective invasion of basal-like tumour cells.

    • Antoine A. Khalil
    • Daan Smits
    • Johan de Rooij
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17