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Showing 1–13 of 13 results
Advanced filters: Author: Martin A. Ivarsson Clear advanced filters

  • Here the authors map the dynamics of human NK cell residency and recirculation, showing that CD56bright NK cells transiently occupy tissues and recirculate via lymphatics, whereas CD56dim NK cells remain vascular except during inflammation.

    • Annika Niehrs
    • Laura Hertwig
    • Niklas K. Björkström
    ResearchOpen Access
    Nature Immunology
    Volume: 26, P: 2004-2015

  • Deep subsurface microorganisms play an important role in nutrient cycling, yet little is known about deep continental fungal communities. Here, the authors show organically preserved and partly mineralized fungi at 740 m depth, and find evidence of an anaerobic fungi and sulfate reducing bacteria consortium.

    • Henrik Drake
    • Magnus Ivarsson
    • Mats E. Åström
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-9

  • Many protein–protein interactions depend on Short Linear Motifs (SLiMs). In this study, the authors use large-scale binding assays, deep mutational scanning, and structural analysis to map SLiMs recognised by human cyclins and uncover the rules that determine their specificity and affinity.

    • Mihkel Örd
    • Matthew J. Winters
    • Norman E. Davey
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 receptor in myeloid cells.

    • Annalaura Mastrangelo
    • Iñaki Robles-Vera
    • David Sancho
    ResearchOpen Access
    Nature
    Volume: 645, P: 254-261

  • Macrophage specific deletion of GGTase-I, a prenylation enzyme, in mice induces inflammatory response and rheumatoid arthritis. Here the authors show that GGTase-I deficiency and the resulting reduction of RAC1 prenylation increase RAC1 interaction with the adaptor protein IQGAP1, leading to GTP-loading of RAC1 and enhanced proinflammatory cytokine production.

    • Murali K. Akula
    • Mohamed X. Ibrahim
    • Martin O. Bergo
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • As an interface between maternal and fetal tissues, decidua hosts immune cells specialized in fostering a successful pregnancy. Here the authors carry out high-dimensional characterization of function, morphology and surface markers of human decidual innate lymphoid cells (ILCs), identifying subsets with features distinct from blood ILC.

    • Oisín Huhn
    • Martin A. Ivarsson
    • Francesco Colucci
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • Here, Zimmer et al. analyze the natural killer (NK) cell response in a patient cohort with acute dengue virus infection showing early NK cell activation and proliferation, and the data suggest that NK cell proliferation depends on IL-18 signaling, and that responding NK cells have a skin-homing phenotype.

    • Christine L. Zimmer
    • Martin Cornillet
    • Niklas K. Björkström
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • Precipitation of 13C-depleted authigenic carbonate is a tracer of sulphate-dependent anaerobic methane oxidation, particularly in marine sediments. Here, the authors present extremely 13C-depleted carbonates from deep granitoid rocks suggesting the presence of microbial sulphate reducers and methane oxidisers.

    • Henrik Drake
    • Mats E. Åström
    • Peter Sjövall
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-9

  • Fractured rocks of impact craters have been suggested to be suitable hosts for deep microbial communities on Earth, and potentially other terrestrial planets, yet direct evidence remains elusive. Here, the authors show that the Siljan impact structure is host to long-term deep methane-cycling microbial activity.

    • Henrik Drake
    • Nick M. W. Roberts
    • Mats E. Åström
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • Transcriptomes of about 70,000 single cells from first-trimester deciduas and placentas reveal subsets of perivascular, stromal and natural killer cells in the decidua, with distinct immunomodulatory profiles that regulate the environment necessary for successful placentation.

    • Roser Vento-Tormo
    • Mirjana Efremova
    • Sarah A. Teichmann
    Research
    Nature
    Volume: 563, P: 347-353