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Showing 1–6 of 6 results
Advanced filters: Author: Martin Gengenbacher Clear advanced filters

  • Drug tolerance complicates the treatment of tuberculosis. Here, Kreutzfeldt et al. show that the protein CinA mediates drug tolerance in Mycobacterium tuberculosis by cleaving NAD-drug adducts, suggesting CinA as a potential target to shorten tuberculosis treatment by potentiating the efficacy of currently used antibiotics.

    • Kaj M. Kreutzfeldt
    • Robert S. Jansen
    • Sabine Ehrt
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • It has been shown that the bioactive component of pyrazinamide, pyrazinoic acid (POA), blocks coenzyme A biosynthesis in M. tuberculosis by binding to the aspartate decarboxylase PanD. Here the authors show that pyrazinamide triggers degradation of PanD by stimulating its degradation by the caseinolytic protease Clp.

    • Pooja Gopal
    • Jickky Palmae Sarathy
    • Thomas Dick
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • Combined CRISPRi chemical genetics and comparative genomics reveal Mycobacterium tuberculosis drug resistance mechanisms and a potential opportunity to repurpose clarithromycin to treat tuberculosis due to inactivation of the whiB7 resistance factor in an entire Mtb sublineage.

    • Shuqi Li
    • Nicholas C. Poulton
    • Jeremy M. Rock
    ResearchOpen Access
    Nature Microbiology
    Volume: 7, P: 766-779

  • The angiopoietins regulate vascular maturation, angiogenesis and lymphangiogenesis via their Tie receptors that were long believed to be endothelium-specific. Here the authors show that angiopoietins activate and control pericyte function through pericyte-expressed Tie2 triggering of Calpain, Akt and FOXO3A signalling cascades.

    • Martin Teichert
    • Laura Milde
    • Hellmut G. Augustin
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12