Autoreactive T cells contribute to the onset of autoimmune diseases but are also detectable in healthy individuals. Here, by examining the dynamics of autoreactive T cell responses to a diabetogenic antigen, the authors show that specific phenotype and T cell receptor repertoire changes are associated with health or disease, with additional cues implicated for this transition.
- Anne Eugster
- Anna Lorenc
- Iria Gomez-Tourino
