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Showing 1–6 of 6 results
Advanced filters: Author: Martin Mück-Häusl Clear advanced filters
  • Here the authors map mesothelial cells across organs, revealing conserved disease-driven states. They identify key genes controlling the shift toward fibrosis and shows that blocking this reprogramming protects lungs, opening new anti-fibrosis strategies.

    • Safwen Kadri
    • Adrian Fischer
    • Yuval Rinkevich
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18
  • Lung fibrosis development involves alveolar macrophages, with mechanisms that are incompletely understood. Here, the authors show that alveolar macrophages mediate the disassembly of pleuro-alveolar junctions, driving fibrosis via connective tissue transfer, and demonstrate that targeting this process can reverse chronic fibrosis in mice.

    • Adrian Fischer
    • Wei Han
    • Yuval Rinkevich
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18
  • Hepatitis B virus (HBV) has a limited host range and current animal models can only recapitulate certain aspects of HBV replication. Here, the authors show that expression of the HBV receptor NTCP in macaques supports HBV replication in vivo, suggesting this as animal model for future HBV studies.

    • Benjamin J. Burwitz
    • Jochen M. Wettengel
    • Jonah B. Sacha
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10
  • Extensive scars develop in deep wounds as opposed to superficial wounds but it is unclear why. Here, the authors use live imaging of physiologic wounds and scars formed ex vivo to show that fascia fibroblasts upregulate N-cadherin allowing coordinated cell migration that drives extensive scar formation of deep wounds.

    • Dongsheng Jiang
    • Simon Christ
    • Yuval Rinkevich
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13