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Showing 1–3 of 3 results
Advanced filters: Author: Martin Meschkat Clear advanced filters

  • Oligodendrocytes myelinate and metabolically support axons. The role of myelination in information processing beyond regulation of conduction velocity is unclear. Here, the authors show that myelination contributes to sustained stimulus perception in the auditory cortex, shaping neuronal responses.

    • Sharlen Moore
    • Martin Meschkat
    • Klaus-Armin Nave
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • Myelin is formed of proteins of long half-lives. The mechanisms of renewal of such a stable structure are unclear. Here, the authors show that myelin integrity requires continuous myelin synthesis at the inner tongue, contributing to the maintenance of a functional axon-myelin unit.

    • Martin Meschkat
    • Anna M. Steyer
    • Wiebke Möbius
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18

  • Efficient repair of demyelinated CNS lesions involves the resolution of inflammation and induction of remyelination. Berghoff et al. show that sterol synthesis in microglia is key to both processes, which can be supported by squalene therapy.

    • Stefan A. Berghoff
    • Lena Spieth
    • Gesine Saher
    Research
    Nature Neuroscience
    Volume: 24, P: 47-60