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Showing 1–3 of 3 results
Advanced filters: Author: Martin Middleditch Clear advanced filters

  • Poly-γ-glutamate tails are a distinctive feature of folate and F420 cofactors, but it was unclear how these tails elongate while maintaining substrate specificity. Here, the authors discover that folylpolyglutamate synthase and γ-glutamyl ligase enzymes add successive L-glutamates to the termini of the growing γ-glutamyl chain in a processive mechanism.

    • Ghader Bashiri
    • Esther M. M. Bulloch
    • Christopher J. Squire
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11

  • Cofactor F420 plays crucial roles in bacterial and archaeal metabolism, but its biosynthetic pathway is not fully understood. Here, the authors present the structure of one of the enzymes and provide experimental evidence for a substantial revision of the pathway, including the identification of a new intermediate.

    • Ghader Bashiri
    • James Antoney
    • Colin J. Jackson
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12