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Showing 1–5 of 5 results
Advanced filters: Author: Martin O’Flaherty Clear advanced filters

  • Burden of major disease is projected to increase in England and many other countries. Here the authors model the impact of reducing eight known risk factors for disease burden, such as BMI and smoking, between 2023-2043 in England and report that reductions in risk factors may not substantially reduce the major illness burden by 2043 due to population ageing.

    • Anna Head
    • Ann Raymond
    • Chris Kypridemos
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Combination of epidemiology, preclinical models and ultradeep DNA profiling of clinical cohorts unpicks the inflammatory mechanism by which air pollution promotes lung cancer

    • William Hill
    • Emilia L. Lim
    • Charles Swanton
    Research
    Nature
    Volume: 616, P: 159-167

  • The heterogeneity of androgen receptor (AR) gene alterations across metastases in prostate cancer remains unresolved. Here, the authors characterise AR genomic complexity across spatially separated lethal metastases from 10 prostate cancer patients and investigate how AR alterations evolve.

    • A. M. Mahedi Hasan
    • Paolo Cremaschi
    • Gerhardt Attard
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • Turajlic and colleagues assess longitudinal antibody and cellular immune responses against SARS-CoV-2 variants of concern in patients with cancer, following either recovery from SARS-CoV-2 infection or vaccination, in two back-to-back reports from the CAPTURE study.

    • Annika Fendler
    • Lewis Au
    • Samra Turajlic
    ResearchOpen Access
    Nature Cancer
    Volume: 2, P: 1321-1337

  • The removal of apoptotic cells by phagocytes is essential for the maintenance of tissue homeostasis and is usually immunologically silent. However, dysregulation of this process is associated with numerous inflammatory and autoimmune diseases, and thus the therapeutic manipulation of apoptotic cell clearance by phagocytes may be a means to treat these diseases.

    • Ivan K. H. Poon
    • Christopher D. Lucas
    • Kodi S. Ravichandran
    Reviews
    Nature Reviews Immunology
    Volume: 14, P: 166-180