Nature Search

High-affinity binding sites for juvenile hormone I in the larval integument of Drosophila hydei

Gerhard Klages
Hans Emmerich
Martin G. Peter
Research17 Jul 1980
Nature

Volume: 286, P: 282-285
Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions

Macrophage specific deletion of GGTase-I, a prenylation enzyme, in mice induces inflammatory response and rheumatoid arthritis. Here the authors show that GGTase-I deficiency and the resulting reduction of RAC1 prenylation increase RAC1 interaction with the adaptor protein IQGAP1, leading to GTP-loading of RAC1 and enhanced proinflammatory cytokine production.

Murali K. Akula
Mohamed X. Ibrahim
Martin O. Bergo
ResearchOpen Access04 Sept 2019
Nature Communications

Volume: 10, P: 1-13
Reduced adipocyte glutaminase activity promotes energy expenditure and metabolic health

Lecoutre, Maqdasy and Rizo-Roca show that whole-body pharmacological inhibition or adipocyte-specific deletion of glutaminase in mice activates thermogenesis in inguinal adipocytes and promotes metabolic health. They also link decreased plasma and adipose tissue glutamine-to-glutamate ratios to insulin resistance in humans with obesity.

Simon Lecoutre
Salwan Maqdasy
Mikael Rydén
ResearchOpen Access15 Jul 2024
Nature Metabolism

Volume: 6, P: 1329-1346
Impaired phosphocreatine metabolism in white adipocytes promotes inflammation

Maqdasy, Lecoutre et al. show that increased an phosphocreatine/creatine ratio in white adipocytes drives changes in AMP-activated protein kinase activity and promotes white adipocyte inflammation during obesity.

Salwan Maqdasy
Simon Lecoutre
Mikael Rydén
ResearchOpen Access14 Feb 2022
Nature Metabolism

Volume: 4, P: 190-202
Transient expression of an adenine base editor corrects the Hutchinson-Gilford progeria syndrome mutation and improves the skin phenotype in mice

Base editing to treat diseases is progressing but tissue delivery and progenitor cells correction are challenging. Here, the authors show sustained effects and propagation of mutation-corrected progenitors by transient adenine base editor expression, improving the skin phenotype of HGPS mice.

Daniel Whisenant
Kayeong Lim
Maria Eriksson
ResearchOpen Access02 Jun 2022
Nature Communications

Volume: 13, P: 1-13
The long noncoding RNA ADIPINT regulates human adipocyte metabolism via pyruvate carboxylase

Adipocyte-expressed long non-coding RNAs (lncRNAs) have been shown to regulate the transcription of genes involved in lipid metabolism. Here the authors describe a human adipocyte-specific lncRNA, ADIPINT, which regulates lipid metabolism in white adipocytes in part through its interaction with the metabolic enzyme pyruvate carboxylase.

Alastair G. Kerr
Zuoneng Wang
Hui Gao
ResearchOpen Access26 May 2022
Nature Communications

Volume: 13, P: 1-16
Control of the innate immune response by the mevalonate pathway

Deficiency in mevalonate kinase causes autoinflammatory disease. Wang and colleagues define the detailed mechanistic basis that leads to this disease phenotype in mice and humans.

Murali K Akula
Man Shi
Donghai Wang
Research06 Jun 2016
Nature Immunology

Volume: 17, P: 922-929
Knockout of the RAS endoprotease RCE1 accelerates myeloid leukemia by downregulating GADD45b

Christin Karlsson
Murali K. Akula
Martin O. Bergo
Research12 May 2020
Leukemia

Volume: 35, P: 606-609
Lymph protects metastasizing melanoma cells from ferroptosis

Melanoma cells undergo less oxidative stress and less ferroptosis in lymph than in blood, owing to higher levels of oleic acid in lymph, and thus exposure to the lymphatic environment increases subsequent metastasis through blood.

Jessalyn M. Ubellacker
Alpaslan Tasdogan
Sean J. Morrison
Research19 Aug 2020
Nature

Volume: 585, P: 113-118
Extra Rabs unsnarl a lipid traffic jam

Niemann–Pick type C (NPC) disease is a fatal lipid-storage disorder caused by a 'lipid traffic jam' in late endosomes and lysosomes. A recent study indicates that overexpression of the vesicular transport proteins Rab7 or Rab9 increases the flow of traffic, allowing accumulated lipids to leave the endosomes and reach the Golgi apparatus and endoplasmic reticulum.

Martin O. Bergo
Stephen G. Young
News & Views01 Jul 2002
Nature Medicine

Volume: 8, P: 662-664
Functional analysis of the regulatory requirements of B-Raf and the B-Raf^V600E oncoprotein

T Brummer
P Martin
M Reth
Research15 May 2006
Oncogene

Volume: 25, P: 6262-6276
SOX9 drives KRAS-induced lung adenocarcinoma progression and suppresses anti-tumor immunity

Hua Zhong
Wen Lu
Sharon R. Pine
Research31 May 2023
Oncogene

Volume: 42, P: 2183-2194
Genomic profiling of the transcription factor Zfp148 and its impact on the p53 pathway

Zhiyuan V. Zou
Nadia Gul
Per Lindahl
ResearchOpen Access25 Aug 2020
Scientific Reports

Volume: 10, P: 1-13
Oncogene-induced senescence underlies the mutual exclusive nature of oncogenic KRAS and BRAF

J Cisowski
V I Sayin
M O Bergo
Research01 Jun 2015
Oncogene

Volume: 35, P: 1328-1333
The MTH1 inhibitor TH588 is a microtubule-modulating agent that eliminates cancer cells by activating the mitotic surveillance pathway

Nadia Gul
Joakim Karlsson
Per Lindahl
ResearchOpen Access11 Oct 2019
Scientific Reports

Volume: 9, P: 1-12
Inactivating GGTase-I reduces disease phenotypes in a mouse model of K-RAS-induced myeloproliferative disease

A-K M Sjogren
K M E Andersson
M O Bergo
Correspondence26 Oct 2010
Leukemia

Volume: 25, P: 186-189
Wild-type KRAS inhibits oncogenic KRAS-induced T-ALL in mice

A Staffas
C Karlsson
M O Bergo
Research05 Nov 2014
Leukemia

Volume: 29, P: 1032-1040

Search

High-affinity binding sites for juvenile hormone I in the larval integument of Drosophila hydei

Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions

Reduced adipocyte glutaminase activity promotes energy expenditure and metabolic health

Impaired phosphocreatine metabolism in white adipocytes promotes inflammation

Transient expression of an adenine base editor corrects the Hutchinson-Gilford progeria syndrome mutation and improves the skin phenotype in mice

The long noncoding RNA ADIPINT regulates human adipocyte metabolism via pyruvate carboxylase

Control of the innate immune response by the mevalonate pathway

Knockout of the RAS endoprotease RCE1 accelerates myeloid leukemia by downregulating GADD45b

Lymph protects metastasizing melanoma cells from ferroptosis

Extra Rabs unsnarl a lipid traffic jam

Functional analysis of the regulatory requirements of B-Raf and the B-Raf^V600E oncoprotein

SOX9 drives KRAS-induced lung adenocarcinoma progression and suppresses anti-tumor immunity

Genomic profiling of the transcription factor Zfp148 and its impact on the p53 pathway

Oncogene-induced senescence underlies the mutual exclusive nature of oncogenic KRAS and BRAF

The MTH1 inhibitor TH588 is a microtubule-modulating agent that eliminates cancer cells by activating the mitotic surveillance pathway

Inactivating GGTase-I reduces disease phenotypes in a mouse model of K-RAS-induced myeloproliferative disease

Wild-type KRAS inhibits oncogenic KRAS-induced T-ALL in mice

Search

Quick links

Search

Filter By:

Search

Quick links