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Showing 1–10 of 10 results
Advanced filters: Author: Martin Thanbichler Clear advanced filters

  • Bacteria have evolved several different mechanisms to target protein complexes, membrane vesicles and DNA to specific positions within the cell. Here, Thanbichler and Shapiro highlight key mechanisms of cellular organization in bacteria, with an emphasis on the role of polymeric protein assemblies in the directed movement and positioning of macromolecular complexes.

    • Martin Thanbichler
    • Lucy Shapiro
    Reviews
    Nature Reviews Microbiology
    Volume: 6, P: 28-40

  • Curved cell shapes are common among bacteria, but the underlying morphogenetic mechanisms are incompletely understood. Here, the authors identify an outer-membrane protein complex that promotes cell curvature in Rhodospirillum rubrum by forming helical ribbon structures that modulate the dynamics of cell wall biosynthesis, biasing cell growth towards the cell’s outer curve.

    • Sebastian Pöhl
    • Giacomo Giacomelli
    • Martin Thanbichler
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-21

  • Protein VirB regulates the expression of virulence genes in the pathogen Shigella flexneri by binding to DNA sequences far upstream of their promoters. Here, Jakob et al. show that VirB acts as a CTP-dependent molecular switch that uses a loading-and-sliding mechanism to control transcription of its target genes.

    • Sara Jakob
    • Wieland Steinchen
    • Martin Thanbichler
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Proteins with a catalytically inactive LytM-type endopeptidase domain regulate cell wall-degrading enzymes in bacteria. Here, Izquierdo-Martinez et al. show that one such protein, DipM, coordinates different peptidoglycan-remodeling pathways to ensure proper cell constriction and daughter cell separation in the model bacterium Caulobacter crescentus.

    • Adrian Izquierdo-Martinez
    • Maria Billini
    • Martin Thanbichler
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18

  • In bacteria, DNA replication and segregation are commonly coupled. Here, by investigating the dynamics of these processes in the marine bacterium Hyphomonas neptunium, the authors unravel a two-step chromosomal segregation process reminiscent of eukaryotic mitosis, providing insights into the evolution of bacterial cell organization.

    • Alexandra Jung
    • Anne Raßbach
    • Martin Thanbichler
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • The roles played by bactofilins, a widespread type of bacterial cytoskeletal elements, are unclear. Here, the authors show that the bactofilins BacNOP facilitate proper subcellular localization of the ParABS chromosome segregation system in the model organism Myxococcus xanthus.

    • Lin Lin
    • Manuel Osorio Valeriano
    • Martin Thanbichler
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16

  • In many bacteria and plasmids, DNA segregation is controlled by the ParABS system, an essential component of which is the formation of a nucleoprotein complex. Here, making use of recent discoveries, the authors develop a sliding and bridging model to predict the fine structure of this complex.

    • Lara Connolley
    • Lucas Schnabel
    • Seán M. Murray
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • The order and variability of bacterial chromosome organization, contained within the distribution of chromosome conformations, are unclear. Here, the authors develop a fully data-driven maximum entropy approach to extract single-cell 3D chromosome conformations from Hi-C experiments on the model organism Caulobacter crescentus.

    • Joris J. B. Messelink
    • Muriel C. F. van Teeseling
    • Chase P. Broedersz
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-9

  • An analysis of the phosphate starvation response in Caulobacter crescentus shows that the extracellular and cytoplasmic phosphate concentrations are sensed by different pathways and play distinct regulatory roles in the adaptation of cells to low-phosphate conditions.

    • Maria Billini
    • Tamara Hoffmann
    • Martin Thanbichler
    ResearchOpen Access
    Communications Biology
    Volume: 7, P: 1-13