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Showing 1–6 of 6 results
Advanced filters: Author: Martina Foglizzo Clear advanced filters

  • Ni, Wei, Vona and colleagues use human brain organoids to dissect patient AIRIM variants associated with neurodevelopmental features. A subset of variants impaired ribosome production and protein synthesis, and delayed radial glial cell specification.

    • Chunyang Ni
    • Yudong Wei
    • Michael Buszczak
    ResearchOpen Access
    Nature Cell Biology
    Volume: 27, P: 1240-1255

  • The BRCC36 isopeptidase complex (BRISC) is a deubiquitylase that stabilizes interferon receptors, driving inflammation. We discovered ‘BRISC molecular glue’ inhibitors (BLUEs) that selectively inactivate BRISC, promoting interferon receptor ubiquitylation and degradation to dampen immune responses.

    • Francesca Chandler
    • Poli Adi Narayana Reddy
    • Elton Zeqiraj
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 32, P: 1812-1824

  • Characterization of a novel mutation in the E2 ubiquitin-conjugating enzyme UBE2A accounts for the decreased activity of the mutant enzyme that underlies disease and provides important insight into the catalytic mechanism of E2s.

    • Martina Foglizzo
    • Catherine L. Day
    News & Views
    Nature Chemical Biology
    Volume: 15, P: 6-7

  • TRAF6 is a RING E3 ligase that builds Lys63-linked ubiquitin chains. Here, the authors present the crystal structure of TRAF6 bound to the Ubc13~Ub conjugate, which, together with biochemical assays, reveals the role of the zinc finger domains and why RING dimerisation is required for TRAF6 activity.

    • Adam J. Middleton
    • Rhesa Budhidarmo
    • Catherine L. Day
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10

  • The Polycomb Repressive-Deubiquitinase (PR-DUB) complex is responsible for the removal of the ubiquitin epigenetic modification from Histone 2A. Here the authors describe the structure of the Drosophila PR-DUB complex, providing new insight into its regulation and how cancer-associated mutations disrupt PR-DUB activity.

    • Martina Foglizzo
    • Adam J. Middleton
    • Peter D. Mace
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15