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Showing 1–3 of 3 results
Advanced filters: Author: Martina Hurwitz Clear advanced filters
  • Aberrant crosstalk between cancer stem cells and their microenvironment triggers angiogenesis and TGFβ signalling, creating conditions that are conducive for hijacking leptin and leptin receptor signalling, which in turn launches downstream PI3K–AKT–mTOR signalling during the benign-to-malignant transition.

    • Shaopeng Yuan
    • Katherine S. Stewart
    • Elaine Fuchs
    ResearchOpen Access
    Nature
    Volume: 612, P: 555-563
  • Schmidt et al. develop and test a platform for the delivery of stereotactic radiotherapy to mouse models. The authors identify maximum tolerated doses for radiation delivered to the mouse lower abdomen and pelvis, and show that while ablative radiotherapy improves survival, it does not cure autochthonous prostate and colorectal tumor models.

    • Daniel R. Schmidt
    • Iva Monique T. Gramatikov
    • Matthew G. Vander Heiden
    ResearchOpen Access
    Communications Medicine
    Volume: 3, P: 1-20