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Inhibition of RNA cleavage but not polyadenylation by a point mutation in mRNA 3′ consensus sequence AAUAAA

Craig Montell
Eric F. Fisher
Arnold J. Berk
Research13 Oct 1983
Nature

Volume: 305, P: 600-605
CerS6-dependent ceramide synthesis in hypothalamic neurons promotes ER/mitochondrial stress and impairs glucose homeostasis in obese mice

Ceramides in peripheral tissues contribute to obesity-related metabolic dysfunction. This study reveals that CerS6-derived ceramides induce hypothalamic lipotoxicity in mice via altered ER/mitochondrial homeostasis.

Philipp Hammerschmidt
Sophie M. Steculorum
Jens C. Brüning
ResearchOpen Access29 Nov 2023
Nature Communications

Volume: 14, P: 1-22

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Inhibition of RNA cleavage but not polyadenylation by a point mutation in mRNA 3′ consensus sequence AAUAAA

CerS6-dependent ceramide synthesis in hypothalamic neurons promotes ER/mitochondrial stress and impairs glucose homeostasis in obese mice

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