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Showing 1–4 of 4 results
Advanced filters: Author: Marvin Hering Clear advanced filters

  • Hepatitis C virus (HCV) variability and its phenotypic consequences aren’t well studied in relation to viral replication fitness and disease severity. Here, the authors identify a replication-enhancing domain in non-structural protein 5A, linking high replication fitness to severe disease outcomes, with implications for understanding HCV pathogenesis in immunocompromised patients.

    • Paul Rothhaar
    • Tomke Arand
    • Volker Lohmann
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • The interaction of Toll-like receptor 4 (TLR4) results in recruitment of proteinacious adapter molecules to the cell membrane. Here Hering and colleagues show that sphinganine recruits adaptor protein MyD88 to TLR4 in the macrophage membrane and the absence of sphinganine in murine models disrupts TLR4 driven inflammation.

    • Marvin Hering
    • Alaa Madi
    • Guoliang Cui
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18