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Showing 1–4 of 4 results
Advanced filters: Author: Marvin L. Hsieh Clear advanced filters

  • The variability in clinical outcomes of SARS-CoV-2 infection is partly due to deficiencies in production or response to type I interferons (IFN). Here, the authors describe a FIP200-dependent lysosomal degradation pathway, independent of canonical autophagy and type I IFN, that restricts SARS-CoV-2 replication, offering insights into critical COVID-19 pneumonia mechanisms.

    • Lili Hu
    • Renee M. van der Sluis
    • Trine H. Mogensen
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-23

  • Here, Chen et. al. characterize the relationship between the gut microbiota and plasma metabolite changes in the context of ST-elevation myocardial infarction (STEMI), unveiling a role of butyrate-producing bacteria and their ketogenesis in post-STEMI cardiac repair, a finding validated in nonhuman primate and mouse models. They show that butyrate supplementation reduces myocardial infarction severity in mice, underscoring the significance of butyrate-producing bacteria and beta-hydroxybutyrate in improving post-MI outcomes.

    • Hung-Chih Chen
    • Yen-Wen Liu
    • Patrick C. H. Hsieh
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • The [4Fe4S]2+ cluster-containing DNA-repair enzyme MUTYH helps safeguard the integrity of Watson–Crick base pairing and the human genetic code. The MUTYH [4Fe4S]2+ cluster mediates DNA redox signalling and DNA lesion identification. Now, a MUTYH pathologic variant associated with catastrophic [4Fe4S]2+ cluster redox degradation, impairment of DNA signalling and human colonic tumorigenesis has been identified.

    • Kevin J. McDonnell
    • Joseph A. Chemler
    • Stephen B. Gruber
    Research
    Nature Chemistry
    Volume: 10, P: 873-880