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Showing 1–18 of 18 results
Advanced filters: Author: Marvin Whiteley Clear advanced filters

  • Competition is fierce in the microbial world, making evolutionary training and fitness essential for a microorganism to survive and thrive. To honour this spirit, in this Essay an expert panel has selected seven special events to make up the inaugural Microbial Olympics.

    • Merry Youle
    • Forest Rohwer
    • S. Craig Cary
    Comments & Opinion
    Nature Reviews Microbiology
    Volume: 10, P: 583-588

  • Microorganisms can form complex, spatially organized communities that are coordinated by both physical and chemical intercellular interactions, as well as by other molecules present in the surrounding environment. Here, Whiteley and colleagues describe a number of microscale techniques for reproducing small bacterial communities in the laboratory. They also discuss the analytical tools available to monitor the impact of spatial organization on both bacterial behaviour and the generation of phenotypic heterogeneity.

    • Aimee K. Wessel
    • Laura Hmelo
    • Marvin Whiteley
    Reviews
    Nature Reviews Microbiology
    Volume: 11, P: 337-348

  • The spatial organization of microbial communities can affect their function, both in the environment and during infections. In this article, Whiteley and colleagues review the factors that govern biogeography during polymicrobial infections and how spatial positioning can influence bacterial virulence. They also discuss how targeting biogeography can be used as a therapeutic strategy.

    • Apollo Stacy
    • Luke McNally
    • Marvin Whiteley
    Reviews
    Nature Reviews Microbiology
    Volume: 14, P: 93-105

  • What makes the human body a good growth medium for bacterial pathogens? In this Review, Brown, Palmer and Whiteley outline how the host growth environment affects disease and discuss the potential for targeting host metabolic pathways for therapeutic development.

    • Stacie A. Brown
    • Kelli L. Palmer
    • Marvin Whiteley
    Reviews
    Nature Reviews Microbiology
    Volume: 6, P: 657-666

  • A study examining bacterial gene expression in human-derived samples identifies a gene encoding a small RNA and describes how it orchestrates the transition between chronic and acute infection in Pseudomonas aeruginosa.

    • Pengbo Cao
    • Derek Fleming
    • Marvin Whiteley
    ResearchOpen Access
    Nature
    Volume: 618, P: 358-364

  • Pseudomonas aeruginosa is a functionally versatile bacterium, a leading opportunistic human pathogen and a model organism in microbiology. In this Review, Letizia, Diggle and Whiteley discuss P. aeruginosa’s quorum sensing, biofilm formation, virulence, epidemiology, resistance mechanisms and infection control strategies.

    • Morgana Letizia
    • Stephen P. Diggle
    • Marvin Whiteley
    Reviews
    Nature Reviews Microbiology
    Volume: 23, P: 701-717

  • In this Perspective, Rumbaugh and Whiteley explore the advantages and limitations of current medical biofilm models and outline a framework for quantitatively assessing model accuracy.

    • Kendra P. Rumbaugh
    • Marvin Whiteley
    Reviews
    Nature Reviews Microbiology
    Volume: 23, P: 57-66

  • Despite advances in peptide synthesis techniques, explicit control over the quaternary structure of synthetic peptides has remained elusive. Now, the dynamic covalent chemistry of hydrazide- and aldehyde-containing peptides has now been shown to enable the formation of unique quaternary structures with topological diversity. Using this method, oligomers were assembled into complex structures showing dramatic enhancements of antimicrobial effectiveness versus Staphylococcus Aureus.

    • James F. Reuther
    • Justine L. Dees
    • Eric V. Anslyn
    Research
    Nature Chemistry
    Volume: 10, P: 45-50

  • A growing body of evidence points to the importance of microcolonies in the dissemination of bacteria, yet there is a dearth of tools for systematically assessing the behavior of cells within such communities. New strategies for landscaping three-dimensional culture environments on microscopic scales may have a critical role in revealing how bacteria orchestrate antibiotic resistance and other social behaviors within small, dense aggregates.

    • Jodi L Connell
    • Marvin Whiteley
    • Jason B Shear
    Comments & Opinion
    Nature Chemical Biology
    Volume: 8, P: 10-13

  • The distinct spatial patterning of microorganisms during infection can influence infection outcomes. In this Review, Azimi et al. detail the microbiogeography of human infections and discuss approaches to study the processes that influence polymicrobial patterning.

    • Sheyda Azimi
    • Gina R. Lewin
    • Marvin Whiteley
    Reviews
    Nature Reviews Microbiology
    Volume: 20, P: 579-592