Nature Search

Polyadenylation of c-mos mRNA as a control point in Xenopus meiotic maturation

Michael D. Sheets
Michael Wu
Marvin Wickens
Research06 Apr 1995
Nature

Volume: 374, P: 511-516
Deviants — or emissaries

Marvin Wickens
Kathy Takayama
News & Views06 Jan 1994
Nature

Volume: 367, P: 17-18
Springtime in the desert

Marvin Wickens
News & Views27 May 1993
Nature

Volume: 363, P: 305-306
Is the Galactic Centre gamma-ray source 1E1740.7 – 2942 accreting from a molecular cloud?

John Bally
Marvin Leventhal
Research19 Sept 1991
Nature

Volume: 353, P: 234-237
The C-terminal domain of RNA polymerase II couples mRNA processing to transcription

Susan McCracken
Nova Fong
David L. Bentley
Research23 Jan 1997
Nature

Volume: 385, P: 357-361
Multifunctional deadenylase complexes diversify mRNA control

Deadenylases shorten mRNA poly(A) tails and thereby regulate mRNA translation and decay. Recent studies have shown that these factors form different complexes. The recruitment of multifunctional deadenylase complexes to target mRNAs provides a unique node to control mRNA translation and decay.

Aaron C. Goldstrohm
Marvin Wickens
Reviews01 Apr 2008
Nature Reviews Molecular Cell Biology

Volume: 9, P: 337-344
RNA regulatory networks diversified through curvature of the PUF protein scaffold

Members of the PUF family of RNA-binding proteins bind multiple mRNAs in vivo. Here the authors show that the S. cerevisiaePuf5p binds targets of varying lengths that correlate with biological functions. The RNA-binding sites adopt different structures to adapt to a fixed protein scaffold.

Daniel Wilinski
Chen Qiu
Marvin Wickens
ResearchOpen Access14 Sept 2015
Nature Communications

Volume: 6, P: 1-11
Unbiased screen of RNA tailing activities reveals a poly(UG) polymerase

Ribonucleotidyl transferases tethered to an RNA reporter add untemplated RNA tails. TRAID-seq identifies the activities of 22 enzymes, including the addition of poly(UG).

Melanie A. Preston
Douglas F. Porter
Marvin Wickens
Research15 Apr 2019
Nature Methods

Volume: 16, P: 437-445
Author Correction: poly(UG)-tailed RNAs in genome protection and epigenetic inheritance

Aditi Shukla
Jenny Yan
Scott Kennedy
Amendments and Corrections14 Apr 2021
Nature

Volume: 592, P: E27
Publisher Correction: Expanding the binding specificity for RNA recognition by a PUF domain

Wei Zhou
Daniel Melamed
Stanley Fields
Amendments and CorrectionsOpen Access27 Jun 2022
Nature Communications

Volume: 13, P: 1
A single spacer nucleotide determines the specificities of two mRNA regulatory proteins

Laura Opperman
Brad Hook
Marvin Wickens
Research23 Oct 2005
Nature Structural & Molecular Biology

Volume: 12, P: 945-951
PUF proteins bind Pop2p to regulate messenger RNAs

Aaron C Goldstrohm
Brad A Hook
Marvin Wickens
Research21 May 2006
Nature Structural & Molecular Biology

Volume: 13, P: 533-539
A higher order PUF complex is central to regulation of C. elegans germline stem cells

PUF proteins, conserved stem cell regulators, maintain germline stem cells with partner proteins in nematodes. Here, authors discover a complex of two FBF-2 PUF proteins and partner LST-1 that represses target mRNA via adjacent regulatory elements.

Chen Qiu
Sarah L. Crittenden
Traci M. Tanaka Hall
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-18
Protein-RNA networks revealed through covalent RNA marks

A fusion of RNA-binding proteins (RBPs) to a poly(U) polymerase allows the tagging of endogenous RNAs bound by the RBPs with a U-tail that can be used to identify the bound RNA by sequencing. RNA tagging is suited to discover RNA-protein networks in vivo.

Christopher P Lapointe
Daniel Wilinski
Marvin Wickens
Research02 Nov 2015
Nature Methods

Volume: 12, P: 1163-1170
C. elegans germ granules require both assembly and localized regulators for mRNA repression

Nematode P granules are cytoplasmic RNA–protein biomolecule condensates central to germ cell development. Here the authors show that dimerization of the PGL-1 scaffolding protein is crucial to granule formation and mRNA repression, and that the WAGO-1 Argonaute protein is a cofactor in repressing PGL-1 bound mRNAs.

Scott Takeo Aoki
Tina R. Lynch
Judith Kimble
ResearchOpen Access12 Feb 2021
Nature Communications

Volume: 12, P: 1-14
poly(UG)-tailed RNAs in genome protection and epigenetic inheritance

In Caenorhabditis elegans, the ribonucleotidyltransferase RDE-3 adds alternating uridine and guanosine ribonucleotides to the 3′ termini of RNAs, a key step in RNA interference and thus epigenetic inheritance in the C. elegans germline.

Aditi Shukla
Jenny Yan
Scott Kennedy
Research20 May 2020
Nature

Volume: 582, P: 283-288
A regulatory cytoplasmic poly(A) polymerase in Caenorhabditis elegans

Liaoteng Wang
Christian R. Eckmann
Judith Kimble
Research19 Sept 2002
Nature

Volume: 419, P: 312-316
A conserved RNA-binding protein controls germline stem cells in Caenorhabditis elegans

Sarah L. Crittenden
David S. Bernstein
Judith Kimble
Research22 May 2002
Nature

Volume: 417, P: 660-663
A conserved RNA-binding protein that regulates sexual fates in the C. elegans hermaphrodite germ line

Beilin Zhang
Maria Gallegos
Marvin P. Wickens
Research04 Dec 1997
Nature

Volume: 390, P: 477-484
Expanding the binding specificity for RNA recognition by a PUF domain

The PUF RNAbinding domain has an eight-repeat structure with the ability to bind an eight-base RNA sequence. Here the authors generate a comprehensive library of variants of a PUF domain to find an RNA binding code and design PUF domains that recognize an arbitrary RNA sequence.

Wei Zhou
Daniel Melamed
Stanley Fields
ResearchOpen Access24 Aug 2021
Nature Communications

Volume: 12, P: 1-15
STAR-studded circuitry

A recent study reports the RNA sequences that bind to the translational repressor protein GLD-1. The data suggest that a network of developmental genes may be regulated by GLD-1 or related STAR proteins through silencing or alternative splicing.

Samuel E Butcher
Marvin Wickens
News & Views01 Jan 2004
Nature Structural & Molecular Biology

Volume: 11, P: 2-3
A conserved PUF–Ago–eEF1A complex attenuates translation elongation

PUF (Pumilio/FBF) RNA-binding proteins and Argonaute (Ago) miRNA-binding proteins regulate mRNAs post-transcriptionally, each acting through similar yet distinct mechanisms. New genetic and biochemical analyses demonstrate that PUF and Ago proteins also function together in complex with elongation factor eEF1A to repress translation elongation.

Kyle Friend
Zachary T Campbell
Judith Kimble
Research08 Jan 2012
Nature Structural & Molecular Biology

Volume: 19, P: 176-183
A protein-RNA specificity code enables targeted activation of an endogenous human transcript

A randomized RNA library is used to determine the specificities of RNA recognition by PUF repeats. The code is then used to design a protein that targets endogenous human cyclin B1 mRNA and activates its translation.

Zachary T Campbell
Cary T Valley
Marvin Wickens
Research29 Jun 2014
Nature Structural & Molecular Biology

Volume: 21, P: 732-738
Establishing sexual dimorphism: conservation amidst diversity?

David Zarkower
Reviews01 Mar 2001
Nature Reviews Genetics

Volume: 2, P: 175-185
RNA in unexpected places: long non-coding RNA functions in diverse cellular contexts

In addition to their roles in chromatin regulation, long non-coding RNAs (lncRNAs) are being characterized as regulators of diverse cell biological processes, including post-transcriptional control, organization of scaffolds and cell signalling. These findings add weight to the notion that lncRNAs provide a flexible resource for rapid cellular control.

Sarah Geisler
Jeff Coller
Reviews09 Oct 2013
Nature Reviews Molecular Cell Biology

Volume: 14, P: 699-712
Sex and the singular DM domain: insights into sexual regulation, evolution and plasticity

This article reviews our growing understanding of the varied roles of DM domain genes in metazoan sexual development: in the evolution of sexually dimorphic traits and new sex-determining mechanisms and, more recently, in maintaining cell fate in the gonad.

Clinton K. Matson
David Zarkower
Reviews07 Feb 2012
Nature Reviews Genetics

Volume: 13, P: 163-174

Search

Polyadenylation of c-mos mRNA as a control point in Xenopus meiotic maturation

Deviants — or emissaries

Springtime in the desert

Is the Galactic Centre gamma-ray source 1E1740.7 – 2942 accreting from a molecular cloud?

The C-terminal domain of RNA polymerase II couples mRNA processing to transcription

Multifunctional deadenylase complexes diversify mRNA control

RNA regulatory networks diversified through curvature of the PUF protein scaffold

Unbiased screen of RNA tailing activities reveals a poly(UG) polymerase

Author Correction: poly(UG)-tailed RNAs in genome protection and epigenetic inheritance

Publisher Correction: Expanding the binding specificity for RNA recognition by a PUF domain

A single spacer nucleotide determines the specificities of two mRNA regulatory proteins

PUF proteins bind Pop2p to regulate messenger RNAs

A higher order PUF complex is central to regulation of C. elegans germline stem cells

Protein-RNA networks revealed through covalent RNA marks

C. elegans germ granules require both assembly and localized regulators for mRNA repression

poly(UG)-tailed RNAs in genome protection and epigenetic inheritance

A regulatory cytoplasmic poly(A) polymerase in Caenorhabditis elegans

A conserved RNA-binding protein controls germline stem cells in Caenorhabditis elegans

A conserved RNA-binding protein that regulates sexual fates in the C. elegans hermaphrodite germ line

Expanding the binding specificity for RNA recognition by a PUF domain

STAR-studded circuitry

A conserved PUF–Ago–eEF1A complex attenuates translation elongation

A protein-RNA specificity code enables targeted activation of an endogenous human transcript

Establishing sexual dimorphism: conservation amidst diversity?

RNA in unexpected places: long non-coding RNA functions in diverse cellular contexts

Sex and the singular DM domain: insights into sexual regulation, evolution and plasticity

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