Phosphoinositide 3-kinase (PI3K) signalling is central in the regulation of cellular function. Here, Vanhaesebroecket al.review the key discoveries that led the identification of the PI3K genes and function to the design of clinical trials with PI3K inhibitors, over a period of less than three decades.
- Bart Vanhaesebroeck
- Len Stephens
- Phillip Hawkins
