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Showing 1–50 of 64 results

Advanced filters: Author: Mary Hynes Clear advanced filters

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

Donna M. Stone
Mary Hynes
Arnon Rosenthal
Research14 Nov 1996
Nature

Volume: 384, P: 129-134
Interaction of plasma membrane fibronectin receptor with talin—a transmembrane linkage

Alan Horwitz
Kimberly Duggan
Keith Burridge
Research10 Apr 1986
Nature

Volume: 320, P: 531-533
Life of the running waters

J. Green
Books & Arts26 Feb 1987
Nature

Volume: 325, P: 769
Matrix mechano-sensing at the invasive front induces a cytoskeletal and transcriptional memory supporting metastasis

Interactions with the extracellular matrix (ECM) control tumor proliferation, invasion and metastasis. Here, authors provide spatial information on ECM organization and how it influences tumor cell invasive and metastasis properties through induction of cytoskeletal and transcriptional memory.

Oscar Maiques
Marta C. Sallan
Victoria Sanz-Moreno
ResearchOpen Access14 Feb 2025
Nature Communications

Volume: 16, P: 1-23
The seven-transmembrane receptor Smoothened cell-autonomously induces multiple ventral cell types

Mary Hynes
Weilan Ye
Arnon Rosenthal
Research01 Jan 2000
Nature Neuroscience

Volume: 3, P: 41-46
High-energy physics: W and Z particles from CERN

P.I. Kalmus
News & Views01 Aug 1983
Nature

Volume: 304, P: 686-687
Measurement of organic carbon in polar snow samples

Mark S. Twickler
Mary Jo Spencer
Paul A. Mayewski
Research13 Mar 1986
Nature

Volume: 320, P: 156-158
The role of turns in the structure of an α-helical protein

Adam P. Brunet
Enoch S. Huang
Michael H. Hecht
Research22 Jul 1993
Nature

Volume: 364, P: 355-358
Mutations in the plakophilin 1 gene result in ectodermal dysplasia/skin fragility syndrome

John A. McGrath
James R. McMillan
Robin A.J. Eady
Research01 Oct 1997
Nature Genetics

Volume: 17, P: 240-244
A 5′-flanking sequence essential for progesterone regulation of an ovalbumin fusion gene

Douglas C. Dean
Brian J. Knoll
Bert W. O'Malley
Research06 Oct 1983
Nature

Volume: 305, P: 551-554
Association between self-reported multimorbidity and longitudinal brain Aβ deposition in Alzheimer’s disease

Whether multimorbidity accelerates brain Aβ deposition in humans remains largely unknown. Here, the authors demonstrate that higher self-reported multimorbidity burden predicts increased brain Aβ accumulation rates in the ADNI cohort.

Xian-Le Bu
Wei Zhu
Kristin Fargher
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-12
LAP1 supports nuclear adaptability during constrained melanoma cell migration and invasion

Jung-Garcia et al. dissect the contributions of isoforms of the inner nuclear membrane protein LAP1 to nuclear envelope blebbing, constrained migration and invasion in melanoma cells.

Yaiza Jung-Garcia
Oscar Maiques
Jeremy G. Carlton
ResearchOpen Access09 Jan 2023
Nature Cell Biology

Volume: 25, P: 108-119
Accelerated re-epithelialization in β₃-integrin-deficient- mice is associated with enhanced TGF-β1 signaling

L E Reynolds
F J Conti
K Hodivala-Dilke
Research16 Jan 2005
Nature Medicine

Volume: 11, P: 167-174
WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion

Amoeboid cells are associated with melanoma invasive capacity. Here, the authors show that the WNT11-FZD7-DAAM1 pathway regulates tumour-initiating potential, invasion and metastasis lead by amoeboid cells in the invasive front of melanoma tumours.

Irene Rodriguez-Hernandez
Oscar Maiques
Victoria Sanz-Moreno
ResearchOpen Access20 Oct 2020
Nature Communications

Volume: 11, P: 1-20
AMPK is a mechano-metabolic sensor linking cell adhesion and mitochondrial dynamics to Myosin-dependent cell migration

Cell metabolism must adapt to the energy needs of migrating cells. This study finds that fast amoeboid migrating cells harbor high AMPK activity, which controls both mitochondrial dynamics and cytoskeletal remodeling, enabling reduced energy needs.

Eva Crosas-Molist
Vittoria Graziani
Victoria Sanz-Moreno
ResearchOpen Access22 May 2023
Nature Communications

Volume: 14, P: 1-22
EGF receptor signaling inhibits keratinocyte apoptosis: evidence for mediation by Bcl-X_L

Stefan W Stoll
Mary Benedict
Gabriel Nuñez
Research31 Mar 1998
Oncogene

Volume: 16, P: 1493-1499
International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways

Primary biliary cirrhosis is an autoimmune liver disease with poor therapeutic options. Here Cordell et al. a perform meta-analysis of European genome-wide association studies identifying six novel risk loci and a number of potential therapeutic pathways.

Heather J. Cordell
Younghun Han
Katherine A. Siminovitch
ResearchOpen Access22 Sept 2015
Nature Communications

Volume: 6, P: 1-11
Activating Smoothened mutations in sporadic basal-cell carcinoma

Jingwu Xie
Maximilien Murone
Frederic J. de Sauvage
Research01 Jan 1998
Nature

Volume: 391, P: 90-92
A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis

Interactions of cells with extracellular matrix are important in normal physiology and cancer metastasis. Here, an extracellular matrix molecule array is developed and used to show that conserved changes in adhesive properties are associated with metastasis, including binding to fibronectin in combination with galectin-3, galectin-8 or laminin.

Nathan E. Reticker-Flynn
David F. Braga Malta
Sangeeta N. Bhatia
Research09 Oct 2012
Nature Communications

Volume: 3, P: 1-12
FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease

In this study the authors identify a possible link between the gene FAM222A and brain atrophy. The protein it encodes is found to accumulate in plaques seen in Alzheimer’s disease, and functional analysis suggests it interacts with amyloid-beta.

Tingxiang Yan
Jingjing Liang
Xinglong Wang
ResearchOpen Access21 Jan 2020
Nature Communications

Volume: 11, P: 1-16
A control oriented strategy of disruption prediction to avoid the configuration collapse of tokamak reactors

Confining plasma and managing disruptions in tokamak devices is a challenge. Here the authors demonstrate a method predicting and possibly preventing disruptions and macroscopic instabilities in tokamak plasma using data from JET.

Andrea Murari
Riccardo Rossi
Michela Gelfusa
ResearchOpen Access18 Mar 2024
Nature Communications

Volume: 15, P: 1-19
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Estimation of reference curves for brain atrophy and analysis of robustness to machine effects

Elodie Piot
Félix Renard
Maria Luisa Mandelli
ResearchOpen Access03 Oct 2025
Scientific Reports

Volume: 15, P: 1-21
A preclinical pipeline to evaluate migrastatics as therapeutic agents in metastatic melanoma

Oscar Maiques
Bruce Fanshawe
Gilbert O. Fruhwirth
ResearchOpen Access25 Jun 2021
British Journal of Cancer

Volume: 125, P: 699-713
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis

Engrafted mesenchymal stem cells (MSCs) promote breast cancer metastasis formation. Breast cancer cells induce MSCs to produce the cytokine CCL5, which then acts on breast tumour cells, enhancing their ability to migrate and extravasate blood vessel at the site of future metastases.

Antoine E. Karnoub
Ajeeta B. Dash
Robert A. Weinberg
Research04 Oct 2007
Nature

Volume: 449, P: 557-563
Enhanced performance in fusion plasmas through turbulence suppression by megaelectronvolt ions

Experiments at the Joint European Torus tokamak show improved thermal ion confinement in the presence of highly energetic ions and Alfvénic instabilities in the plasma.

S. Mazzi
J. Garcia
I. Zychor
Research30 Jun 2022
Nature Physics

Volume: 18, P: 776-782
Prostaglandin E₂ production and metabolism in human breast cancer cells and breast fibroblasts. Regulation by inflammatory mediators

MP Schrey
KV Patel
Research01 Dec 1995
British Journal of Cancer

Volume: 72, P: 1412-1419
Neurodevelopmental outcome of preterm infants enrolled in myo-inositol randomized controlled trial

Ira Adams-Chapman
Kristi L. Watterberg
Marian Willinger
Research23 Mar 2021
Journal of Perinatology

Volume: 41, P: 2072-2087
Relationships of PGRN with sTREM2 in AD continuum and non-AD pathophysiology and their reciprocal roles in modulating amyloid pathology: two population-based study

Liang-Yu Huang
Chen-Chen Tan
Dariella Fernandez
ResearchOpen Access08 Jul 2025
Translational Psychiatry

Volume: 15, P: 1-11
Author Correction: FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease

Tingxiang Yan
Jingjing Liang
Xinglong Wang
Amendments and CorrectionsOpen Access11 Jul 2022
Nature Communications

Volume: 13, P: 1-2
Herstatin inhibits heregulin-mediated breast cancer cell growth and overcomes tamoxifen resistance in breast cancer cells that overexpress HER-2

Farida Jhabvala-Romero
Adam Evans
Gail Mary Clinton
Research06 Nov 2003
Oncogene

Volume: 22, P: 8178-8186
Evaluation of the economic impact of modified screening criteria for retinopathy of prematurity from the Postnatal Growth and ROP (G-ROP) study

John A. F. Zupancic
Gui-shuang Ying
Gui-shuang Ying
Research28 Feb 2020
Journal of Perinatology

Volume: 40, P: 1100-1108
Effect of estradiol on estrogen receptor-α gene expression and activity can be modulated by the ErbB2/PI 3-K/Akt pathway

Gerald E Stoica
Thomas F Franke
Adriana Stoica
Research11 Sept 2003
Oncogene

Volume: 22, P: 7998-8011
Molecular plasticity of human melanoma cells

Mary J C Hendrix
Elisabeth A Seftor
Richard E B Seftor
Reviews19 May 2003
Oncogene

Volume: 22, P: 3070-3075
Identifying healthy individuals with Alzheimer’s disease neuroimaging phenotypes in the UK Biobank

Azevedo et al. conduct a machine learning-based analysis of structural MRI data from multiple cohorts. The authors identify Alzheimer’s disease-like neuroimaging phenotypes associated with poorer cognitive performance in a healthy UK Biobank cohort, potentially highlighting a population at risk of Alzheimer’s disease.

Tiago Azevedo
Richard A. I. Bethlehem
Gail Li
ResearchOpen Access20 Jul 2023
Communications Medicine

Volume: 3, P: 1-15
A telescope GWAS analysis strategy, based on SNPs-genes-pathways ensamble and on multivariate algorithms, to characterize late onset Alzheimer’s disease

Margherita Squillario
Giulia Abate
Kristin Fargher
ResearchOpen Access21 Jul 2020
Scientific Reports

Volume: 10, P: 1-12
Predicting Short-term MCI-to-AD Progression Using Imaging, CSF, Genetic Factors, Cognitive Resilience, and Demographics

Yogatheesan Varatharajah
Vijay K. Ramanan
Kristin Fargher
ResearchOpen Access19 Feb 2019
Scientific Reports

Volume: 9, P: 1-15
Challenges and Opportunities with Causal Discovery Algorithms: Application to Alzheimer’s Pathophysiology

Xinpeng Shen
Sisi Ma
Kristin Fargher
ResearchOpen Access19 Feb 2020
Scientific Reports

Volume: 10, P: 1-12
Genome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways

Emrin Horgusluoglu-Moloch
Shannon L. Risacher
Kristin Fargher
ResearchOpen Access10 Oct 2019
Scientific Reports

Volume: 9, P: 1-12
Disruption prediction with artificial intelligence techniques in tokamak plasmas

Tokamak plasmas are prone to sudden collapses that terminate the nuclear fusion reactions. This perspective discusses the prediction of these so-called disruptions with artificial intelligence techniques.

J. Vega
A. Murari
I. Zychor
Reviews06 Jun 2022
Nature Physics

Volume: 18, P: 741-750
Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits

Yuetiva Deming
Jian Xia
Carlos Cruchaga
ResearchOpen Access04 Jan 2016
Scientific Reports

Volume: 6, P: 1-17
Pattern Discovery in Brain Imaging Genetics via SCCA Modeling with a Generic Non-convex Penalty

Lei Du
Kefei Liu
Kristin Fargher
ResearchOpen Access25 Oct 2017
Scientific Reports

Volume: 7, P: 1-14
A predictive model using the mesoscopic architecture of the living brain to detect Alzheimer’s disease

Inglese et al. develop a predictive model that computes multi-regional statistical morpho-functional mesoscopic traits from T1-weighted magnetic resonance imaging scans. Their model reliably discriminates people with Alzheimer’s disease-related pathologies from those without.

Marianna Inglese
Neva Patel
Eric O. Aboagye
ResearchOpen Access20 Jun 2022
Communications Medicine

Volume: 2, P: 1-16
Clinical validation of cutoff target ranges in newborn screening of metabolic disorders by tandem mass spectrometry: A worldwide collaborative project

David M S McHugh
Cynthia A Cameron
Wendy M Zakowicz
Research15 Feb 2011
Genetics in Medicine

Volume: 13, P: 230-254
Staging tau pathology with tau PET in Alzheimer’s disease: a longitudinal study

Shi-Dong Chen
Jia-Ying Lu
Michelle Zmuda
ResearchOpen Access18 Sept 2021
Translational Psychiatry

Volume: 11, P: 1-12
Correlation between Alzheimer’s disease and type 2 diabetes using non-negative matrix factorization

Yeonwoo Chung
Hyunju Lee
Kristin Fargher
ResearchOpen Access27 Jul 2021
Scientific Reports

Volume: 11, P: 1-14
Plasma phosphorylated-tau181 as a predictive biomarker for Alzheimer’s amyloid, tau and FDG PET status

Xue-Ning Shen
Yu-Yuan Huang
Michelle Zmuda
ResearchOpen Access13 Nov 2021
Translational Psychiatry

Volume: 11, P: 1-10
Metatranscriptomics of N₂-fixing cyanobacteria in the Amazon River plume

Jason A Hilton
Brandon M Satinsky
Jonathan P Zehr
Research16 Dec 2014
The ISME Journal

Volume: 9, P: 1557-1569
Heregulin-β1 regulates the estrogen receptor-α gene expression and activity via the ErbB2/PI 3-K/Akt pathway

Gerald E Stoica
Thomas F Franke
Adriana Stoica
Research10 Apr 2003
Oncogene

Volume: 22, P: 2073-2087
A blood-based signature of cerebrospinal fluid Aβ_1–42 status

Benjamin Goudey
Bowen J. Fung
Brenda Plassman
ResearchOpen Access11 Mar 2019
Scientific Reports

Volume: 9, P: 1-12

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