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Showing 1–5 of 5 results
Advanced filters: Author: Mary Valcanis Clear advanced filters

  • The implementation of genomics for identification and surveillance of antimicrobial resistance (AMR) in clinical laboratories remains challenging. Here, Sherry et al. present a bioinformatics platform for detection of AMR determinants from whole-genome sequencing data, suitable for clinical and public-health microbiology reporting.

    • Norelle L. Sherry
    • Kristy A. Horan
    • Torsten Seemann
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • Salmonella enterica serovar 4,[5],12:i:- (Salmonella 4,[5],12:i:-) is a major pathogen of humans and animals with a reported incidence in Australia three times higher than the UK and USA. Here, the authors report the circulation, antimicrobial resistance signatures, and effects on host cells, of three Salmonella4,[5],12:i:- lineages within Australia.

    • Danielle J. Ingle
    • Rebecca L. Ambrose
    • Deborah A. Williamson
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • Shigella sonnei is one of the main species causing shigellosis worldwide. Here the authors analyse nearly 400 S. sonnei genome sequences and carry out experimental evolution experiments to shed light into the evolutionary processes underlying the recent emergence of fluoroquinolone resistance in this pathogen.

    • Hao Chung The
    • Christine Boinett
    • Stephen Baker
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Vanessa Wong and colleagues report whole-genome sequencing of 1,832 Salmonella enterica serovar Typhi isolates from 63 endemic countries. They identify mutations that define the multidrug resistant (MDR) H58 lineage and report numerous inter- and intracontinental transmissions of this lineage as well as an ongoing MDR typhoid epidemic in Africa.

    • Vanessa K Wong
    • Stephen Baker
    • Gordon Dougan
    Research
    Nature Genetics
    Volume: 47, P: 632-639

  • Typhoid fever is caused by Salmonella enterica serovar Typhi (S. Typhi). This study examines ∼2,000 clinical isolates of S. Typhi to show highly structured/geographically restricted genomes except rapidly disseminating H58 subclade, and design a genotyping framework for tracking the disease.

    • Vanessa K. Wong
    • Stephen Baker
    • Ben Amos
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11