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FOXJ1 mediates taxane resistance through regulation of microtubule dynamics

Taxanes, such as docetaxel or cabazitaxel, are one of the few chemotherapy options for metastatic castration-resistant prostate cancer (mCRPC). Here, the authors discover that FOXJ1 modulation of microtubule dynamics regulates resistance to docetaxel in mCRPC.

Fang Xie
Ada Gjyrezi
Steven P. Balk
ResearchOpen Access14 Feb 2026
Nature Communications

Volume: 17, P: 1-17
FOXA2 rewires AP-1 for transcriptional reprogramming and lineage plasticity in prostate cancer

The role of the FOXA1 to FOXA2 switch in the regulation of the response to androgen receptor signalling inhibition and lineage plasticity in prostate cancer remains unclear. Here, the authors highlight the function of FOXA2 in rewiring AP-1 to induce differential transcriptional reprogramming and lineage plasticity.

Zifeng Wang
Scott L. Townley
Changmeng Cai
ResearchOpen Access08 Jun 2024
Nature Communications

Volume: 15, P: 1-20
Drug resistant pancreatic cancer cells exhibit altered biophysical interactions with stromal fibroblasts in imaging studies of 3D co-culture models

Eric Struth
Maryam Labaf
Jonathan P. Celli
ResearchOpen Access05 Sept 2024
Scientific Reports

Volume: 14, P: 1-11

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