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Advanced filters: Author: Masahito Watari Clear advanced filters

  • Rhodopsin phosphodiesterase (Rh-PDE) hydrolyzes both cAMP and cGMP in a light-dependent manner. Structural and functional analyses of the Rh-PDE from Salpingoeca rosetta reveal unusual rhodopsin topology comprising 8 transmembrane helices (TMs) and suggest that TM0 plays a crucial role in the enzymatic photoactivity.

    • Tatsuya Ikuta
    • Wataru Shihoya
    • Osamu Nureki
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12