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The DNA replication machinery transmits dual signals to prevent unscheduled licensing and execution of centrosome duplication

Cell division requires strict control of DNA replication and centrosome duplication. Here, the authors reveal that DNA replication machinery transmits dual signals to control proper timing of centrosome duplication for genome stability

Kyohei Matsuhashi
Kei K. Ito
Daiju Kitagawa
ResearchOpen Access08 Sept 2025
Nature Communications

Volume: 16, P: 1-18
The microRNA miR-235 couples blast-cell quiescence to the nutritional state

A microRNA, miR-235, is identified that acts downstream of the insulin/insulin growth factor signalling pathway to modulate the quiescence of blast cells in Caenorhabditis elegans.

Hidefumi Kasuga
Masamitsu Fukuyama
Toshiaki Katada
Research05 May 2013
Nature

Volume: 497, P: 503-506
Regulatory mechanism of cold-inducible diapause in Caenorhabditis elegans

Dormancy is induced by a cold environment. Here, the authors found that C. elegans undergoes diapause at low temperatures, namely cold-inducible diapause (CID). CID can be induced by the hsf-1 mutation and is regulated by neural pathways and longevity genes.

Makoto Horikawa
Masamitsu Fukuyama
Masaki Mizunuma
ResearchOpen Access10 Jul 2024
Nature Communications

Volume: 15, P: 1-18
Molecular basis promoting centriole triplet microtubule assembly

Centrioles are characterized by an atypical triplet microtubule structure. Here, the authors discover that the ciliopathy protein HYLS1 promotes the assembly of triplet microtubules within human centrioles.

Yutaka Takeda
Takumi Chinen
Daiju Kitagawa
ResearchOpen Access22 Mar 2024
Nature Communications

Volume: 15, P: 1-15
Patched regulates lipid homeostasis by controlling cellular cholesterol levels

Cellular cholesterol levels are tightly regulated. Here, the authors show that the hedgehog signalling receptor PTCH is a cholesterol transporter. Reduction in PTCH activity leads to cellular cholesterol accumulation, changes in nuclear hormone receptor activity and fatty acid metabolism.

Carla E. Cadena del Castillo
J. Thomas Hannich
Anne Spang
ResearchOpen Access12 Aug 2021
Nature Communications

Volume: 12, P: 1-13
Comparative analysis of multiple DNA double-strand break repair pathways in CRISPR-mediated endogenous tagging

Comparative analysis of multiple DNA double-strand break repair pathways reveals their complex interplay in CRISPR knock-in and offers new strategies for improving precise gene editing efficiency.

Chiharu Tei
Shoji Hata
Daiju Kitagawa
ResearchOpen Access13 May 2025
Communications Biology

Volume: 8, P: 1-12
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
An antioxidant screen identifies ascorbic acid for prevention of light-induced mitotic prolongation in live cell imaging

Ascorbic acid alleviates phototoxic effects of fluorescence live imaging in mitosis, allowing for very high temporal resolution without photodamage.

Tomoki Harada
Shoji Hata
Daiju Kitagawa
ResearchOpen Access01 Nov 2023
Communications Biology

Volume: 6, P: 1-12
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
The impact of the metabolic syndrome and its components on the incidence of ischemic heart disease and stroke: the Japan public health center-based study

Hiroyuki Noda
Hiroyasu Iso
Shoichiro Tsugane
Research27 Feb 2009
Hypertension Research

Volume: 32, P: 289-298

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The DNA replication machinery transmits dual signals to prevent unscheduled licensing and execution of centrosome duplication

The microRNA miR-235 couples blast-cell quiescence to the nutritional state

Regulatory mechanism of cold-inducible diapause in Caenorhabditis elegans

Molecular basis promoting centriole triplet microtubule assembly

Patched regulates lipid homeostasis by controlling cellular cholesterol levels

Comparative analysis of multiple DNA double-strand break repair pathways in CRISPR-mediated endogenous tagging

Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

An antioxidant screen identifies ascorbic acid for prevention of light-induced mitotic prolongation in live cell imaging

Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

The impact of the metabolic syndrome and its components on the incidence of ischemic heart disease and stroke: the Japan public health center-based study

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