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Showing 1–3 of 3 results
Advanced filters: Author: Masanori Okaniwa Clear advanced filters

  • CENP-E regulates chromosome alignment during mitosis to distribute chromosomes equally into daughter cells. Here, the authors show that CENP-E inhibition causes p53-mediated post-mitotic apoptosis in tumours where the spindle assembly checkpoint is compromised, suggesting that CENP-E is a therapeutic target for these cancers.

    • Akihiro Ohashi
    • Momoko Ohori
    • Kentaro Iwata
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-16

  • Here the authors investigate lipid nanodiscs as drug carriers for antitumour immunotherapy. They demonstrate that flexible lipid nanodiscs functionalized with STING-activating cyclic dinucleotides exhibit superior tumour penetration and tumour cell uptake compared with spherical liposomes, resulting in improved antitumour T-cell priming and tumour regression.

    • Eric L. Dane
    • Alexis Belessiotis-Richards
    • Darrell J. Irvine
    ResearchOpen Access
    Nature Materials
    Volume: 21, P: 710-720

  • Inhibitors of the mTOR kinase are in clinical trials for the treatment of cancer; here, mutations in mTOR that can lead to drug resistance are investigated and the results are used to design a new class of mTOR inhibitors that can overcome this resistance.

    • Vanessa S. Rodrik-Outmezguine
    • Masanori Okaniwa
    • Kevan M. Shokat
    Research
    Nature
    Volume: 534, P: 272-276