Calcitonin gene-related peptide (CGRP) regulates inflammation through receptor activity-modifying protein 1 (RAMP1), a subunit of CGRP receptor. This study reveals that RAMP1 signaling in immune cells enhances lipopolysaccharide-induced lymphangiogenesis in the diaphragm, which contributes to improving lymphatic drainage from peritoneal fluid.
- Seri Tsuru
- Yoshiya Ito
- Masataka Majima