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Showing 1–7 of 7 results
Advanced filters: Author: Masataka Yanagawa Clear advanced filters

  • A newly identified phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2)-binding site reveals multivalent interactions between β-arrestins (βarrs) and PtdIns(4,5)P2 that facilitate G-protein-coupled receptor (GPCR)–βarr complex formation within specific membrane domains, revealing a mechanism for spatiotemporal control of GPCR signaling.

    • Ritsuki Kuramoto
    • Tatsuya Ikuta
    • Asuka Inoue
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 21, P: 1927-1937

  • GPCR kinases (GRKs) phosphorylate active-form G-protein-coupled receptors (GPCRs). Here, the authors reveal that Gq heterotrimer coupled with the angiotensin II type-1 receptor (AT1R) determines the GRK subtypes recruited to the complex in a microdomain, thus defining subsequent AT1R phosphorylation patterns, β-arrestin conformation and functionality.

    • Kouki Kawakami
    • Masataka Yanagawa
    • Asuka Inoue
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • A comprehensive analysis of the relationship between Gα proteins and GPCR-regulated transcriptional response elements using Gα-protein knockout cells reveals that these response elements integrate signals from multiple Gα proteins with limited specificity.

    • Ayaki Saito
    • Ryoji Kise
    • Asuka Inoue
    ResearchOpen Access
    Communications Biology
    P: 1-9

  • Receptor dimerization is central to many GPCRs signaling, but key rate and equilibrium constants are hard to measure. Here, the authors present single-molecule methods to obtain such constants and reveal transient opioid receptor homodimers modulating function.

    • Peng Zhou
    • Taka A. Tsunoyama
    • Akihiro Kusumi
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-23

  • Sato et al. show that pinopsin, an extraocular opsin, is also expressed in a subpopulation of retinal photoreceptor cells in lower vertebrates. Its retinal expression coupled to its low thermal isomerization rate suggests that pinopsin can function as a visual pigment and provides some insights into the evolution of scotopic vision in vertebrates.

    • Keita Sato
    • Takahiro Yamashita
    • Yoshinori Shichida
    ResearchOpen Access
    Communications Biology
    Volume: 1, P: 1-10