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Showing 1–7 of 7 results
Advanced filters: Author: Matúš Medo Clear advanced filters

  • Various biological and chemical processes leave characteristic patterns, mutational signatures, in the genome. Here the authors assess tools for fitting known mutational signatures to sequenced samples (to determine the signature contributions to each individual sample), finding that they are all prone to underfitting due to the activity of unknown signatures.

    • Matúš Medo
    • Charlotte K. Y. Ng
    • Michaela Medová
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11

  • The role of mutations within long noncoding RNAs (lncRNAs) exons on tumour cell fitness remains to be explored. Here, the authors investigate the landscape of driver lncRNAs in primary and metastatic samples and validate the functional significance of single nucleotide variants in the NEAT1 oncogene in vitro and in vivo.

    • Roberta Esposito
    • Andrés Lanzós
    • Rory Johnson
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-21

  • Identifying potential mechanisms behind opinion formation is key to curb the spread of misinformation and fake news. Here, the authors propose a model of opinion formation on a network of relations of trust and distrust between subjects, and show that opinion instability increases with the complexity and size of the system, proposing a candidate mechanism for how trust towards deceptive sources develops.

    • Matúš Medo
    • Manuel S. Mariani
    • Linyuan Lü
    ResearchOpen Access
    Communications Physics
    Volume: 4, P: 1-10