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Showing 1–2 of 2 results
Advanced filters: Author: Mateusz Putyrski Clear advanced filters

  • The SpyTag/SpyCatcher protein ligation technology is valuable in many applications, but few methods exist for controlling reactivity. Here the authors report a method for controlling SpyCatcher activity via S-thiolation of engineered cysteines, demonstrating the value of their technology for the rapid generation of bispecific antibodies.

    • Christian Hentrich
    • Mateusz Putyrski
    • Francisco Ylera
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • The fibrinolytic system promotes the progression of solid tumors. Here, the authors show that the fibrinolytic agent plasmin supports B-cell acute lymphoblastic leukemia (B-ALL) progression via remodeling of the extracellular matrix, and the inhibition of plasmin activation with ε-aminocaproic acid prolongs survival in B-ALL mouse models.

    • Valentina R. Minciacchi
    • Jimena Bravo
    • Daniela S. Krause
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19