Nature Search

Multi-omic definition of metabolic obesity through adipose tissue–microbiome interactions

Metabolomics, metagenomics, proteins and genetics were combined with clinical data to define a metabolic signature of obesity.

Rima M. Chakaroun
Meenakshi Pradhan
Fredrik Bäckhed
ResearchOpen Access02 Jan 2026
Nature Medicine

Volume: 32, P: 113-125
C-COMPASS: a user-friendly neural network tool profiles cell compartments at protein and lipid levels

C-COMPASS is an open-source software designed to predict the spatial cellular distribution of proteins and lipids from cellular organelle profiling using a neural network-based regression model.

Daniel T. Haas
Daniel Weindl
Natalie Krahmer
ResearchOpen Access04 Dec 2025
Nature Methods

Volume: 23, P: 118-130
Genome-wide association analysis of plasma lipidome identifies 495 genetic associations

The human plasma lipidome captures risk for cardiometabolic diseases. Here, the authors perform univariate and multivariate genome-wide analyses of 179 lipid species in 7174 Finnish individuals, revealing genetic links between diseases and lipid species beyond the standard lipids HDL-Cholesterol, LDL-Cholesterol, Triglycerides, and total Cholesterol.

Linda Ottensmann
Rubina Tabassum
Matti Pirinen
ResearchOpen Access31 Oct 2023
Nature Communications

Volume: 14, P: 1-15
Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes

Wigger, Barovic and Brunner et al. perform a multidimensional analysis of islets from metabolically characterized patients who had undergone pancreatectomy, observing remarkable heterogeneity between samples from individuals with type 2 diabetes, thus arguing against models of linear beta-cell dedifferentiation in diabetes.

Leonore Wigger
Marko Barovic
Michele Solimena
Research28 Jun 2021
Nature Metabolism

Volume: 3, P: 1017-1031
Elucidating the nature of the proton radioactivity and branching ratio on the first proton emitter discovered ^53mCo

Since the discovery of proton radioactivity in ^53mCo, there has been no direct measurement of its branching ratio. Here the authors report the first measurement of the weak proton decay in ^53mCo by combining results from advanced detection systems.

Luis G. Sarmiento
Thomas Roger
Annika Voss
ResearchOpen Access25 Sept 2023
Nature Communications

Volume: 14, P: 1-7
Revitalizing membrane rafts: new tools and insights

Ten years ago, the cell biological role of lipid rafts was controversial owing to limited methodology and confusing nomenclature. Through technical advances, our concept of lipid rafts has evolved into that of dynamic nanoscale assemblies that can be stabilized to control signalling and membrane trafficking.

Kai Simons
Mathias J. Gerl
Reviews23 Sept 2010
Nature Reviews Molecular Cell Biology

Volume: 11, P: 688-699
Genetic architecture of human plasma lipidome and its link to cardiovascular disease

Cardiovascular diseases (CVD) are associated with plasma lipid levels. Here, Tabassum et al. perform genome-wide association studies for lipidomic profiles with 141 (non-standard) lipid species which highlights shared genetic loci with CVD and that traditional lipids have low genetic correlation with other lipids.

Rubina Tabassum
Joel T. Rämö
Samuli Ripatti
ResearchOpen Access24 Sept 2019
Nature Communications

Volume: 10, P: 1-14
Identification of biomarkers for glycaemic deterioration in type 2 diabetes

There is an urgent need for biomarkers for type 2 diabetes progression that provide a deeper understanding of the disease process. Here, the authors identify biomarkers in three molecular classes, replicate them in other cohorts and explore top protein biomarkers in detail in functional studies.

Roderick C. Slieker
Louise A. Donnelly
Guy A. Rutter
ResearchOpen Access03 May 2023
Nature Communications

Volume: 14, P: 1-18
Cholesterol is Inefficiently Converted to Cholesteryl Esters in the Blood of Cardiovascular Disease Patients

Mathias J. Gerl
Winchil L. C. Vaz
Otilia V. Vieira
ResearchOpen Access03 Oct 2018
Scientific Reports

Volume: 8, P: 1-11
A set of gene knockouts as a resource for global lipidomic changes

Aleksandra Spiegel
Chris Lauber
Mathias J. Gerl
ResearchOpen Access22 Jun 2022
Scientific Reports

Volume: 12, P: 1-14
Mouse lipidomics reveals inherent flexibility of a mammalian lipidome

Michał A. Surma
Mathias J. Gerl
Christian Klose
ResearchOpen Access29 Sept 2021
Scientific Reports

Volume: 11, P: 1-14
Enlightening discriminative network functional modules behind Principal Component Analysis separation in differential-omic science studies

Sara Ciucci
Yan Ge
Carlo Vittorio Cannistraci
ResearchOpen Access13 Mar 2017
Scientific Reports

Volume: 7, P: 1-24
Large-scale human skin lipidomics by quantitative, high-throughput shotgun mass spectrometry

Tomasz Sadowski
Christian Klose
Michal A. Surma
ResearchOpen Access07 Mar 2017
Scientific Reports

Volume: 7, P: 1-11

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