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Showing 1–9 of 9 results
Advanced filters: Author: Mathias Munschauer Clear advanced filters

  • Interactions between SARS-CoV-2 viral RNAs and host cell proteins during infection are evaluated to improve our understanding of viral RNA functions and the host innate immune response.

    • Nora Schmidt
    • Caleb A. Lareau
    • Mathias Munschauer
    ResearchOpen Access
    Nature Microbiology
    Volume: 6, P: 339-353

  • Specific functions of viral helicases in genome replication of RNA viruses are widely unknown. This study suggests that hepatitis C virus NS3 helicase unwinds stem loop structures at the 3’end of the genome, thereby facilitating (−) strand synthesis.

    • Philipp Ralfs
    • Stéphane Bressanelli
    • Volker Lohmann
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-21

  • Despite some well-characterized functions in cancer, the impact of most long non-coding RNAs remains unknown. Here, the authors discover the lncRNA lincNMR which is upregulated in cancer and drives cell proliferation by interacting with YBX1 and controlling nucleotide metabolism.

    • Minakshi Gandhi
    • Matthias Groß
    • Sven Diederichs
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • Infection with SARS-COV-2 can result in self-limited upper airway infection or progress to a more systemic inflammatory condition including pneumonic COVID-19. Here the authors utilise a multi-omics approach to interrogate the immune response of patients with self-limiting upper respiratory SARS-CoV-2 infection and reveal a temporal immune trajectory they associate with viral containment and restriction from pneumonic progressive disease.

    • Kami Pekayvaz
    • Alexander Leunig
    • Leo Nicolai
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-21

  • RNA-recognition elements are identified for the fragile-X-syndrome-associated RNA-binding protein FMRP, in addition to its target messenger RNAs; although many of FMRP gene targets discovered are involved in brain function and autism spectrum disorder, a proportion are also dysregulated in mouse ovaries, suggesting cross-regulation of signalling pathways in different tissues.

    • Manuel Ascano
    • Neelanjan Mukherjee
    • Thomas Tuschl
    Research
    Nature
    Volume: 492, P: 382-386