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Showing 1–3 of 3 results
Advanced filters: Author: Mathieu Quesnel-Vallieres Clear advanced filters

  • RNA splicing variations could help identify cancer subtypes, but this task is computationally challenging. Here, the authors develop CHESSBOARD, a Bayesian tile finding algorithm for splicing data which identifies patterns in the form of tiles and can discover leukemia subgroups associated with therapeutic response.

    • David Wang
    • Mathieu Quesnel-Vallieres
    • Yoseph Barash
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • Multiple alternative splicing events in CD19 mRNA have been associated with resistance/relapse to CD19 CAR-T therapy in patients with B cell malignancies. Here, by combining patient data and a high-throughput mutagenesis screen, the authors identify single point mutations and RNA-binding proteins that can control CD19 splicing and be associated with CD19 CAR-T therapy resistance.

    • Mariela Cortés-López
    • Laura Schulz
    • Julian König
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • Transcriptome profiling in different brain regions has revealed distinct patterns of gene and non-coding RNA expression, as well as alternative splicing, in autism spectrum disorder (ASD). The authors review these ASD-associated signatures and the resulting mechanistic insights into ASD.

    • Mathieu Quesnel-Vallières
    • Robert J. Weatheritt
    • Benjamin J. Blencowe
    Reviews
    Nature Reviews Genetics
    Volume: 20, P: 51-63