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Showing 1–3 of 3 results
Advanced filters: Author: Matilde Marini Clear advanced filters

  • Non-steroidal anti-inflammatory drugs (NSAIDs) are known to alleviate pain by reducing inflammation. To the contrary, here, the authors show that selective inhibition of the prostaglandin E2 receptor (EP2) in Schwann cells eliminates pain without disrupting the protective and healing functions of inflammation.

    • Romina Nassini
    • Lorenzo Landini
    • Pierangelo Geppetti
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • Endometriosis affects over 60% of women, leading to widespread pain. Here, the authors show that blocking C5a receptor (C5aR1) in Schwann cells reduces pain by inhibiting pathways that trigger inflammation, oxidative stress, and nerve sensitivity, revealing a potential therapeutic target in endometriosis pain management.

    • Mustafa Titiz
    • Lorenzo Landini
    • Francesco De Logu
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • The mechanism of CGRP-evoked peripheral pain is unclear. Here, the authors show that the CGRP-mediated neuronal/Schwann cell pathway mediates allodynia associated with neurogenic inflammation, contributing to the algesic action of CGRP in mice.

    • Francesco De Logu
    • Romina Nassini
    • Pierangelo Geppetti
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-19