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Advanced filters: Author: Matileen Grace Cranick Clear advanced filters

  • A new acid-degradable linker termed ‘azido-acetal’ has been developed that rapidly hydrolyses at pH 6.0 but is stable at pH 7.4. Lipid nanoparticles made with this linker delivered mRNA in vivo and in vitro better than traditional lipid nanoparticles.

    • Sheng Zhao
    • Kewa Gao
    • Niren Murthy
    Research
    Nature Nanotechnology
    Volume: 19, P: 1702-1711