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Showing 1–18 of 18 results

Advanced filters: Author: Matt A. Roth Clear advanced filters

Pharmacodynamics of Akt drugs revealed by a kinase-modulated bioluminescent indicator

Measuring pharmacodynamics (PD) is vital for drug development but traditional PD studies are labor and resource intensive. Wu et al. introduce a kinase-modulated bioluminescent indicator for noninvasive visualization of Akt-related drug PD in living animals.

Yan Wu
Chenzhou Hao
Michael Z. Lin
Research11 Feb 2025
Nature Chemical Biology

Volume: 21, P: 1194-1204
A generic non-invasive neuromotor interface for human-computer interaction

A high-bandwidth neuromotor interface offers performant out-of-the-box generalization across people.

Patrick Kaifosh
Thomas R. Reardon
Danny Zlobinsky
ResearchOpen Access23 Jul 2025
Nature

Volume: 645, P: 702-711
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

A human–SARS-CoV-2 protein interaction map highlights cellular processes that are hijacked by the virus and that can be targeted by existing drugs, including inhibitors of mRNA translation and predicted regulators of the sigma receptors.

David E. Gordon
Gwendolyn M. Jang
Nevan J. Krogan
Research30 Apr 2020
Nature

Volume: 583, P: 459-468
The diffuse γ-ray background is dominated by star-forming galaxies

The diffuse, isotropic background of gamma rays comes mainly from star-forming galaxies, according to a physical model of gamma-ray emission.

Matt A. Roth
Mark R. Krumholz
Silvia Celli
Research15 Sept 2021
Nature

Volume: 597, P: 341-344
Slack K⁺ channels limit kainic acid-induced seizure severity in mice by modulating neuronal excitability and firing

Mice lacking the Na ⁺ -activated K⁺ channel, Slack, exhibit increased severity of acute kainic-acid induced seizures, suggesting a crucial role for this channel in neuronal excitability.

David Skrabak
Helmut Bischof
Robert Lukowski
ResearchOpen Access11 Oct 2023
Communications Biology

Volume: 6, P: 1-12
An asymmetric electron-scattering photosphere around optical tidal disruption events

Spectropolarimetric observations of three tidal disruption events reveal that they are optically polarized at the 1–2% level by a cloud of electrons surrounding the black hole (in good agreement with theory).

Giorgos Leloudas
Mattia Bulla
Enrico Ramirez-Ruiz
Research29 Sept 2022
Nature Astronomy

Volume: 6, P: 1193-1202
A common flanking variant is associated with enhanced stability of the FGF14-SCA27B repeat locus

Analysis of the FGF14-SCA27B repeat locus identifies a common 5′-flanking insertion that represents the major allele, is present exclusively on nonpathogenic alleles, enhances repeat stability and increases chromatin accessibility.

David Pellerin
Giulia F. Del Gobbo
Matt C. Danzi
Research27 Jun 2024
Nature Genetics

Volume: 56, P: 1366-1370
Lab-on-chip analyser for the in situ determination of dissolved manganese in seawater

Felix Geißler
Eric P. Achterberg
Douglas Wallace
ResearchOpen Access27 Jan 2021
Scientific Reports

Volume: 11, P: 1-13
Genomic architecture of migration timing in a long-distance migratory songbird

Evelien de Greef
Alexander Suh
Kevin C. Fraser
ResearchOpen Access10 Feb 2023
Scientific Reports

Volume: 13, P: 1-7
Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Chris Varghese
Luke Peters
Caroline Reinke
ResearchOpen Access26 Aug 2025
npj Digital Medicine

Volume: 8, P: 1-16
A diet-change modulates the previously established bacterial gut community in juvenile brown trout (Salmo trutta)

Stéphanie C. Michl
Matt Beyer
Carsten Schulz
ResearchOpen Access20 Feb 2019
Scientific Reports

Volume: 9, P: 1-12
Competitive growth in a cooperative mammal

In wild Kalahari meerkats (Suricata suricatta), subordinates of both sexes respond to experimentally induced increases in the growth of same-sex rivals by raising their own growth rate and food intake.

Elise Huchard
Sinead English
Tim Clutton-Brock
Research25 May 2016
Nature

Volume: 533, P: 532-534
Noninvasive Evaluation of the Time Course of Change in Cardiac Function in Spontaneously Hypertensive Rats by Echocardiography

Manabu Kokubo
Arata Uemura
Toyoaki Murohara
Research01 Jul 2005
Hypertension Research

Volume: 28, P: 601-609
Light microenvironment and single-cell gradients of carbon fixation in tissues of symbiont-bearing corals

Daniel Wangpraseurt
Mathieu Pernice
Michael Kühl
Research04 Aug 2015
The ISME Journal

Volume: 10, P: 788-792
Finishing mitosis, one step at a time

The successful completion of mitosis requires that late mitotic events occur in a strict sequence. This is regulated, at least in part, by the order in which different cyclin-dependent kinase substrates are dephosphorylated and in which anaphase-promoting complex substrates are degraded.

Matt Sullivan
David O. Morgan
Reviews01 Nov 2007
Nature Reviews Molecular Cell Biology

Volume: 8, P: 894-903
Uncovering the genetic architecture of broad antisocial behavior through a genome-wide association study meta-analysis

Jorim J. Tielbeek
Emil Uffelmann
Danielle Posthuma
Research25 Oct 2022
Molecular Psychiatry

Volume: 27, P: 4453-4463
Optimized testing strategy for the diagnosis of GAA-FGF14 ataxia/spinocerebellar ataxia 27B

Céline Bonnet
David Pellerin
Mathilde Renaud
ResearchOpen Access15 Jun 2023
Scientific Reports

Volume: 13, P: 1-11
Functional genomic signatures of sponge bacteria reveal unique and shared features of symbiosis

Torsten Thomas
Doug Rusch
Staffan Kjelleberg
Research03 Jun 2010
The ISME Journal

Volume: 4, P: 1557-1567