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Showing 1–8 of 8 results

Advanced filters: Author: Matt Teater Clear advanced filters

T follicular helper cells transiently unlock a plasticity state in germinal centre B cells during the humoral immune response

Scourzic et al. show that germinal centre B cells display an enhanced ability to reprogram to induced pluripotent stem cells compared to mature B cells. This ability indicates their higher plasticity level and is T follicular helper cell-dependent.

Laurianne Scourzic
Franco Izzo
Effie Apostolou
Research29 Dec 2025
Nature Cell Biology

Volume: 28, P: 35-48
Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation

Melnick and colleagues show that the cohesin complex exhibits dose-dependent regulation of chromatin remodeling that accompanies the transition of germinal center B cells to plasma cells, which is necessary to prevent lymphomagenesis.

Martín A. Rivas
Cem Meydan
Ari M. Melnick
Research11 Jan 2021
Nature Immunology

Volume: 22, P: 240-253
AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis

In diffuse large B-cell lymphoma (DLBCL) increased epigenetic heterogeneity in the form of cytosine methylation is known to link to a poor clinical outcome. Here, the authors show that AICDA, an enzyme required for DLBCL pathogenesis, increases cytosine methylation heterogeneity.

Matt Teater
Pilar M. Dominguez
Rita Shaknovich
ResearchOpen Access15 Jan 2018
Nature Communications

Volume: 9, P: 1-10
EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop

The histone methyltransferase EZH2 silences genes by generating H3K27me3 marks. Here the authors use a 3D GC organoid and show EZH2 mediates germinal centre (GC) formation through epigenetic silencing of CDKN1A and release of cell cycle checkpoints.

Wendy Béguelin
Martín A. Rivas
Ari M. Melnick
ResearchOpen Access12 Oct 2017
Nature Communications

Volume: 8, P: 1-16
Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture

Mutations in histone H1 induce the remodelling of chromatin architecture to a more relaxed state, which leads to malignant transformation through changes in histone modifications and the expression of stem cell genes.

Nevin Yusufova
Andreas Kloetgen
Ari M. Melnick
Research09 Dec 2020
Nature

Volume: 589, P: 299-305
The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencing

Parsa et al. report a mechanism of lymphoma initiation involving cooperation of BCL2 and increased activity of the metabolic enzyme SHMT2, which imparts changes in DNA and histone methylation.

Sara Parsa
Ana Ortega-Molina
Hans-Guido Wendel
Research22 Jun 2020
Nature Cancer

Volume: 1, P: 653-664
Reply to "Uveal melanoma cells are resistant to EZH2 inhibition regardless of BAP1 status"

Lindsay M LaFave
Wendy Béguelin
Ross L Levine
Correspondence07 Jun 2016
Nature Medicine

Volume: 22, P: 578-579
Loss of BAP1 function leads to EZH2-dependent transformation

BAP1 regulation of EZH2 provides therapeutic opportunities in cancer.

Lindsay M LaFave
Wendy Béguelin
Ross L Levine
Research05 Oct 2015
Nature Medicine

Volume: 21, P: 1344-1349