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Showing 1–3 of 3 results
Advanced filters: Author: Matteo Ciciani Clear advanced filters

  • Cas9 proteins require a target-adjacent sequence, the PAM, in order to cleave DNA. Here the authors develop a pipeline to accurately predict PAM sequences in order to facilitate the identification of Cas9s targeting specific sequences, including mutations.

    • Matteo Ciciani
    • Michele Demozzi
    • Nicola Segata
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-8

  • A metagenomic survey of babies attending the first year of nursery detected extensive baby-to-baby microbial strain transmission, pointing to social interactions in infancy as crucial drivers of infant microbiome development.

    • Liviana Ricci
    • Vitor Heidrich
    • Nicola Segata
    ResearchOpen Access
    Nature
    Volume: 651, P: 191-200

  • Cas9 nucleases hold clinical significance for genome editing therapies. Here the authors characterize CoCas9, a compact, efficient and precise Cas9 from the human microbiome, and show that delivery via AAV vectors enables efficient editing in the mouse retina, expanding the genome editing toolbox.

    • Eleonora Pedrazzoli
    • Michele Demozzi
    • Anna Cereseto
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12