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Genetic tracing and topography of spontaneous and stimulated cardiac regeneration in mice

Secco et al. develop a genetic tracing method, CycleTrack, to monitor cardiac regeneration. CycleTrack visualizes cardiomyocyte turnover in neonatal and adult mice, after myocardial infarction, and upon stimulation with pro-regenerative microRNAs.

Ilaria Secco
Ana Backovic
Mauro Giacca
ResearchOpen Access07 Mar 2025
Nature Cardiovascular Research

Volume: 4, P: 397-411
The K219T-Lamin mutation induces conduction defects through epigenetic inhibition of SCN5A in human cardiac laminopathy

Mutation of LMNA, encoding Lamin A/C nuclear proteins, cause dilated cardiomyopathy and conduction disorders. Here, the authors show that patient-specific iPSC-derived CMs carrying the K219T LMNA mutation have downregulated Na_v1.5 channels due to dynamic cooperation of Lamin A/C and Polycomb repressor complex 2 at the SCN5A promoter.

Nicolò Salvarani
Silvia Crasto
Elisa Di Pasquale
ResearchOpen Access22 May 2019
Nature Communications

Volume: 10, P: 1-16
Functional screening identifies miRNAs inducing cardiac regeneration

The human heart regenerates poorly, causing insufficient healing after injury; here, microRNAs screened for the ability to induce cardiomyocyte proliferation are shown to stimulate cardiac regeneration and almost complete recovery of the heart after infarction.

Ana Eulalio
Miguel Mano
Mauro Giacca
Research05 Dec 2012
Nature

Volume: 492, P: 376-381
AAV-mediated in vivo functional selection of tissue-protective factors against ischaemia

Cell-based screening assays allow functional testing of chemicals but do not mimic the in vivosituation well. Here, the authors report a method for the discovery of secreted cytoprotective factors in mice and use it to demonstrate that the hormone ghrelin protects cardiac muscle from ischaemic damage.

Giulia Ruozi
Francesca Bortolotti
Mauro Giacca
ResearchOpen Access11 Jun 2015
Nature Communications

Volume: 6, P: 1-15
Interplay between negative symptoms, time spent doing nothing, and negative emotions in patients with schizophrenia spectrum disorders: results from a 37-site study

Giulio D’Anna
Cristina Zarbo
Salvatore Zizolfi
ResearchOpen Access21 Sept 2023
Schizophrenia

Volume: 9, P: 1-10
Shared and distinct abnormalities in sleep-wake patterns and their relationship with the negative symptoms of Schizophrenia Spectrum Disorder patients

Ahmad Mayeli
Alice D. LaGoy
Fabio Ferrarelli
Research14 Apr 2023
Molecular Psychiatry

Volume: 28, P: 2049-2057
MiR-320a as a Potential Novel Circulating Biomarker of Arrhythmogenic CardioMyopathy

Elena Sommariva
Yuri D’Alessandra
Claudio Tondo
ResearchOpen Access06 Jul 2017
Scientific Reports

Volume: 7, P: 1-10

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Genetic tracing and topography of spontaneous and stimulated cardiac regeneration in mice

The K219T-Lamin mutation induces conduction defects through epigenetic inhibition of SCN5A in human cardiac laminopathy

Functional screening identifies miRNAs inducing cardiac regeneration

AAV-mediated in vivo functional selection of tissue-protective factors against ischaemia

Interplay between negative symptoms, time spent doing nothing, and negative emotions in patients with schizophrenia spectrum disorders: results from a 37-site study

Shared and distinct abnormalities in sleep-wake patterns and their relationship with the negative symptoms of Schizophrenia Spectrum Disorder patients

MiR-320a as a Potential Novel Circulating Biomarker of Arrhythmogenic CardioMyopathy

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Genetic tracing and topography of spontaneous and stimulated cardiac regeneration in mice

The K219T-Lamin mutation induces conduction defects through epigenetic inhibition of SCN5A in human cardiac laminopathy

Functional screening identifies miRNAs inducing cardiac regeneration

AAV-mediated in vivo functional selection of tissue-protective factors against ischaemia

Interplay between negative symptoms, time spent doing nothing, and negative emotions in patients with schizophrenia spectrum disorders: results from a 37-site study

Shared and distinct abnormalities in sleep-wake patterns and their relationship with the negative symptoms of Schizophrenia Spectrum Disorder patients

MiR-320a as a Potential Novel Circulating Biomarker of Arrhythmogenic CardioMyopathy

Search

Quick links