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Patient-derived organoids from endometrial disease capture clinical heterogeneity and are amenable to drug screening

Boretto et al. demonstrate that organoids derived from patients with various types of endometrial pathologies can model disease traits and diversity, and can be used as a drug-screening tool.

Matteo Boretto
Nina Maenhoudt
Hugo Vankelecom
Research01 Aug 2019
Nature Cell Biology

Volume: 21, P: 1041-1051
Recapitulating the adenoma–carcinoma sequence by selection of four spontaneous oncogenic mutations in mismatch-repair-deficient human colon organoids

Mizutani et al. use a model that recapitulates the colon adenoma–carcinoma transition through the sequential elimination of media factors leading to spontaneous accumulation of hotspot mutations of mismatch-repair-deficient tumors.

Tomohiro Mizutani
Matteo Boretto
Hans Clevers
ResearchOpen Access01 Nov 2024
Nature Cancer

Volume: 5, P: 1852-1867
One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids

CRISPR base editing technologies can be used for disease modelling. Here the authors use various base editing tools to generate tumour models in human adult stem cell-derived hepatocyte, endometrial and intestinal organoids.

Maarten H. Geurts
Shashank Gandhi
Hans Clevers
ResearchOpen Access17 Aug 2023
Nature Communications

Volume: 14, P: 1-18
Functional expression of the mechanosensitive PIEZO1 channel in primary endometrial epithelial cells and endometrial organoids

Aurélie Hennes
Katharina Held
Joris Vriens
ResearchOpen Access11 Feb 2019
Scientific Reports

Volume: 9, P: 1-14
Major depletion of SOX2⁺ stem cells in the adult pituitary is not restored which does not affect hormonal cell homeostasis and remodelling

Heleen Roose
Benoit Cox
Hugo Vankelecom
ResearchOpen Access05 Dec 2017
Scientific Reports

Volume: 7, P: 1-11

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Patient-derived organoids from endometrial disease capture clinical heterogeneity and are amenable to drug screening

Recapitulating the adenoma–carcinoma sequence by selection of four spontaneous oncogenic mutations in mismatch-repair-deficient human colon organoids

One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids

Functional expression of the mechanosensitive PIEZO1 channel in primary endometrial epithelial cells and endometrial organoids

Major depletion of SOX2+ stem cells in the adult pituitary is not restored which does not affect hormonal cell homeostasis and remodelling

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Major depletion of SOX2⁺ stem cells in the adult pituitary is not restored which does not affect hormonal cell homeostasis and remodelling