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Showing 1–3 of 3 results
Advanced filters: Author: Matteo Gianesello Clear advanced filters

  • Metastasis arises from disseminated tumour cells (DTCs) while the underlying mechanism of DTCs plasticity remains underexplored. Here, the authors show that spatially organized oncogenic enhancers on chromatin sustain the establishment of retinoic acid (RA)-stimulated transcriptional memory through activation of SOX9, supporting the escape of quiescent DTCs from NK-mediated immune surveillance.

    • Daniela Michelatti
    • Sven Beyes
    • Alessio Zippo
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-24

  • Group 3 medulloblastoma (MB) is considered one of the most aggressive forms of this cancer. Here, the authors show that Otx2 and c-MYC oncogenes can drive Group 3 MB formation in mouse and human cerebellar organoids while SMARCA4 overexpression or a EZH2-specific inhibitor can inhibit tumorigenesis.

    • Claudio Ballabio
    • Marica Anderle
    • Luca Tiberi
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-18