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Showing 1–9 of 9 results

Advanced filters: Author: Matteo S. Pizzuto Clear advanced filters

Advancements in pathogen immunity and signaling

The EMBO workshop ‘Pathogen Immunity and Signaling’, held in San Servolo, Italy, from 8 to 12 April 2024, aimed to discuss cutting-edge advances in the understanding of antimicrobial defense mechanisms.

Mads Gyrd-Hansen
Anna Kajaste-Rudnitski
Matteo Iannacone
News & Views15 Jul 2024
Nature Immunology

Volume: 25, P: 1322-1325
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Research11 Mar 2021
Nature

Volume: 593, P: 136-141
Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity

The spike protein of the Omicron variant of SARS-CoV-2 has a higher affinity for ACE2 than Delta, and a marked change in its antigenicity increases Omicron’s evasion of therapeutic and vaccine-elicited neutralizing antibodies.

Bo Meng
Adam Abdullahi
Ravindra K. Gupta
ResearchOpen Access01 Feb 2022
Nature

Volume: 603, P: 706-714
Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift

Pseudovirus assays and surface plasmon resonance show that the Omicron receptor-binding domain binds to human ACE2 with increased affinity relative to the ancestral virus, and that most neutralizing antibodies are considerably less potent against Omicron.

Elisabetta Cameroni
John E. Bowen
Davide Corti
Research23 Dec 2021
Nature

Volume: 602, P: 664-670
A pan-influenza antibody inhibiting neuraminidase via receptor mimicry

The neuraminidase-targeting monoclonal antibody FNI9 potently inhibits the enzymatic activity of influenza A and B viruses via receptor mimicry.

Corey Momont
Ha V. Dang
Matteo Samuele Pizzuto
ResearchOpen Access31 May 2023
Nature

Volume: 618, P: 590-597
Broad sarbecovirus neutralization by a human monoclonal antibody

The human monoclonal antibody S2X259 cross-reacts with spike proteins from all clades of sarbecovirus, and provides prophylactic and therapeutic protection in vivo against parental SARS-CoV-2 and emerging variants of concern.

M. Alejandra Tortorici
Nadine Czudnochowski
Matteo Samuele Pizzuto
Research19 Jul 2021
Nature

Volume: 597, P: 103-108
SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape

A survey of SARS-CoV-2 RBD antibodies identifies those with activity against diverse SARS-CoV-2 variants and SARS-related coronaviruses, highlighting epitopes and features to prioritize in antibody and vaccine development.

Tyler N. Starr
Nadine Czudnochowski
Gyorgy Snell
Research14 Jul 2021
Nature

Volume: 597, P: 97-102
Author Correction: A pan-influenza antibody inhibiting neuraminidase via receptor mimicry

Corey Momont
Ha V. Dang
Matteo Samuele Pizzuto
Amendments and CorrectionsOpen Access05 Jul 2023
Nature

Volume: 619, P: E50
Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E24