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Showing 1–3 of 3 results
Advanced filters: Author: Matthew A. Dragovich Clear advanced filters

  • The platelets detect and respond to shear stress generated by blood flow. Here the authors show that the binding of the soluble von Willebrand factor to its receptor GPIba under physiological shear stress induces receptor's domain unfolding on the platelet and signalling into the platelet, leading to platelets clearance.

    • Wei Deng
    • Yan Xu
    • Renhao Li
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13

  • Bivalent protein degraders such as proteolysis targeting chimeras (PROTACs) are entering clinical trials, with a current focus on oral administration. O’Brien Laramy et al. propose that implementing non-oral drug delivery technologies guided by pharmacokinetic–pharmacodynamic modelling could expand the chemical design space for degraders as well as the number of druggable targets.

    • Matthew N. O’Brien Laramy
    • Suman Luthra
    • Derek W. Bartlett
    Reviews
    Nature Reviews Drug Discovery
    Volume: 22, P: 410-427