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Showing 1–6 of 6 results
Advanced filters: Author: Matthew A. Zurenski Clear advanced filters

  • The cGAS-STING pathway senses cytosolic DNA to activate interferon responses, but has also been implicated in autophagy induction. Here the authors show that, during herpes simplex virus infection, cGAS-induced autophagy is mediated by TBK1-induced TRIM23 phosphorylation and downstream signaling events to assist in antiviral immunity.

    • Dhiraj Acharya
    • Zuberwasim Sayyad
    • Michaela U. Gack
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • An HLA- and gluten-dependent mouse model of coeliac disease with villous atrophy provides evidence for the cooperative role of IL-15 and gluten-specific CD4+ T cells in licensing the full activation of cytotoxic T cells that are necessary for inducing epithelial damage.

    • Valérie Abadie
    • Sangman M. Kim
    • Bana Jabri
    Research
    Nature
    Volume: 578, P: 600-604

  • TRIM23 is identified as an essential regulator of virus-induced autophagy that mediates restriction to several RNA and DNA viruses. K27-mediated ubiquitylation activates TRIM23 GTPase activity, triggering its relocalization and selective autophagy.

    • Konstantin M. J. Sparrer
    • Sebastian Gableske
    • Michaela U. Gack
    Research
    Nature Microbiology
    Volume: 2, P: 1543-1557