Nature Search

p53-mediated accumulation of hypophosphorylated pRb after the G₁ restriction point fails to halt cell cycle progression

Steven P Linke
Matthew P Harris
Geoffrey M Wahl
Research17 Jul 1997
Oncogene

Volume: 15, P: 337-345
Loss of MAT2A compromises methionine metabolism and represents a vulnerability in H3K27M mutant glioma by modulating the epigenome

Agnihotri and colleagues show that loss of the MAT2A enzyme of the methionine cycle induces a global depletion of H3K36me3 and extends survival in glioma models, representing a potential therapeutic vulnerability.

Brian J. Golbourn
Matthew E. Halbert
Sameer Agnihotri
Research14 Apr 2022
Nature Cancer

Volume: 3, P: 629-648
The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location

Single-cell RNA-seq and ATAC-seq, combined with spatial transcriptomics, identify age- and location-related cellular dynamics of diffuse midline gliomas, such as variable oligodendrocyte precursor-like tumor stem cell populations and increased mesenchymal states with age.

Ilon Liu
Li Jiang
Mariella G. Filbin
ResearchOpen Access05 Dec 2022
Nature Genetics

Volume: 54, P: 1881-1894
Author Correction: Loss of MAT2A compromises methionine metabolism and represents a vulnerability in H3K27M mutant glioma by modulating the epigenome

Brian J. Golbourn
Matthew E. Halbert
Sameer Agnihotri
Amendments and Corrections23 Jun 2022
Nature Cancer

Volume: 3, P: 899
Gene expression across mammalian organ development

The transcriptomes of seven major organs across developmental stages from several mammalian species are used for comparative analyses of gene expression and evolution across organ development.

Margarida Cardoso-Moreira
Jean Halbert
Henrik Kaessmann
Research26 Jun 2019
Nature

Volume: 571, P: 505-509
The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models

The Microarray Quality Control consortium pitted 36 teams against each other to evaluate methods for creating genomic classifiers, computational tools for interpreting gene expression profiles. The performance of the classifiers on blinded validation data—and metadata on the analytic methods—reveal the challenges facing the field.

Leming Shi
Gregory Campbell
Russell D Wolfinger
Research30 Jul 2010
Nature Biotechnology

Volume: 28, P: 827-838
Endogenous p53 regulation and function in early stage Friend virus-induced tumor progression differs from that following DNA damage

Linda L Kelley
Geoffrey G Hicks
H Earl Ruley
Research04 Sept 1998
Oncogene

Volume: 17, P: 1119-1130
Brain cancer stem cells: resilience through adaptive plasticity and hierarchical heterogeneity

This Review discusses molecular circuitry underlying adaptive plasticity in brain cancer stem cells, highlighting the transcriptional classification of the stem cell state, neoplastic evolution and development of therapeutic resilience, and critical brain-specific microenvironmental inputs with the goal of informing next-generation stem-targeted treatment paradigms.

Ryan C. Gimple
Kailin Yang
Jeremy N. Rich
Reviews16 Jun 2022
Nature Reviews Cancer

Volume: 22, P: 497-514

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