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Showing 1–6 of 6 results
Advanced filters: Author: Matthew Hangauer Clear advanced filters

  • Williams et al. report a growth arrest mechanism in residual cancer persister cells through targeted therapy-induced upregulation of type I interferon signalling, which is negatively regulated by apoptotic DNA endonuclease DFFB to allow tumour relapse.

    • August F. Williams
    • David A. G. Gervasio
    • Matthew J. Hangauer
    ResearchOpen Access
    Nature Cell Biology
    Volume: 27, P: 2143-2151

  • Epigenetic changes associated with post-natal differentiation have been characterized. Here the authors generate epigenomic and transcriptional profiles from primary human breast cells, providing insights into the transcriptional and epigenetic events that define post-natal cell differentiation in vivo.

    • Philippe Gascard
    • Misha Bilenky
    • Martin Hirst
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-10

  • This study describes the integrative analysis of 111 reference human epigenomes, profiled for histone modification patterns, DNA accessibility, DNA methylation and RNA expression; the results annotate candidate regulatory elements in diverse tissues and cell types, their candidate regulators, and the set of human traits for which they show genetic variant enrichment, providing a resource for interpreting the molecular basis of human disease.

    • Anshul Kundaje
    • Wouter Meuleman
    • Manolis Kellis
    ResearchOpen Access
    Nature
    Volume: 518, P: 317-330

  • Resistance to therapy remains the biggest challenge to achieving cures in patients with cancer. In this Roadmap, Russo et al. overview the field of cancer drug-tolerant persister cells providing paths to advance our understanding of their biology with innovative technologies and recommend strategies to therapeutically target them to ensure that more prolonged responses are achieved in patients with cancer.

    • Mariangela Russo
    • Mengnuo Chen
    • Alberto Bardelli
    Reviews
    Nature Reviews Cancer
    Volume: 24, P: 694-717