Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–14 of 14 results
Advanced filters: Author: Matthew Harries Clear advanced filters

  • DNA-sequencing data from primary tumours and paired metastases from participants in the TRACERx lung study and PEACE autopsy programme are used to analyse the metastatic diversity of advanced non-small cell lung cancer and the seeding patterns that underpin it.

    • Sonya Hessey
    • Abigail Bunkum
    • Mariam Jamal-Hanjani
    ResearchOpen Access
    Nature
    Volume: 653, P: 911-922

  • High-depth sequencing of non-cancerous tissue from patients with metastatic cancer reveals single-base mutational signatures of alcohol, smoking and cancer treatments, and reveals how exogenous factors, including cancer therapies, affect somatic cell evolution.

    • Oriol Pich
    • Sophia Ward
    • Nicholas McGranahan
    ResearchOpen Access
    Nature
    Volume: 653, P: 900-910

  • Mixed responses to targeted therapy within a patient are a clinical challenge. Here the authors show that TP53 loss-of-function cooperates with whole genome doubling which increases chromosomal instability. This leads to greater cellular diversity and multiple routes of resistance, which in turn promotes mixed responses to treatment.

    • Sebastijan Hobor
    • Maise Al Bakir
    • Charles Swanton
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-21

  • Major histocompatibility complex (MHC) loss of heterozygosity, allele-specific mutation and measurement of expression and repression (MHC Hammer) detects disruption to human leukocyte antigens due to mutations, loss of heterogeneity, altered gene expression or alternative splicing. Applied to lung and breast cancer datasets, the tool shows that these aberrations are common across cancer and can have clinical implications.

    • Clare Puttick
    • Thomas P. Jones
    • Nicholas McGranahan
    ResearchOpen Access
    Nature Genetics
    Volume: 56, P: 2121-2131

  • Frontal fibrosing alopecia (FFA) features lichenoid cutaneous inflammation and scarring hair loss. Here, Tziotzios et al. identify four genetic loci associated with FFA by GWAS followed by Bayesian fine-mapping, co-localisation and HLA imputation which highlights HLA-B*07:02 as a risk factor.

    • Christos Tziotzios
    • Christos Petridis
    • John A. McGrath
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-9

  • Immune lymphocyte estimation from nucleotide sequencing (ImmuneLENS) infers B cell and T cell fractions from whole-genome sequencing data. Applied to the 100,000 Genomes Project datasets, circulating T cell fraction provides sex-dependent and prognostic insights in patients.

    • Robert Bentham
    • Thomas P. Jones
    • Nicholas McGranahan
    ResearchOpen Access
    Nature Genetics
    Volume: 57, P: 694-705

  • Patient-derived xenografts are important tools for cancer drug development. Here, the authors develop models from 22 non-small cell lung cancer patients. They show genomic differences between models created from different spatial regions of tumours and a bottleneck on model establishment.

    • Robert E. Hynds
    • Ariana Huebner
    • Charles Swanton
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-21

  • On 12 February 2025, a joint meeting of the UK Aging Networks was held in Liverpool, UK. It was convened by the ECMage (extracellular matrix aging) network and EuroAgeNet, an initiative led by ECMage but involving four other UK aging networks — namely, the building links in aging science and translation network (BLAST), the cognitive frailty interdisciplinary network (CFIN), the aging and nutrient sensing network (AGENTS) and the food systems for older people (Food4Years) network — together with industrial and European partners. In this Meeting Report, we summarize the opinions of an industrial panel and round-table discussions on barriers and opportunities related to academic–industrial partnerships.

    • Joe Swift
    • Angela Cucchi
    • Elizabeth G. Canty-Laird
    News & Views
    Nature Aging
    Volume: 5, P: 2153-2157