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Showing 1–15 of 15 results
Advanced filters: Author: Matthew J. Belousoff Clear advanced filters

  • The structure of GLP-1R and its G protein in complex with the small molecule TT-OAD2 sheds light on how the TT-OAD2 agonist can activate the receptor and provides insights into the development of therapeutic agents for metabolic disorders.

    • Peishen Zhao
    • Yi-Lynn Liang
    • Denise Wootten
    Research
    Nature
    Volume: 577, P: 432-436

  • Cagrilintide is a long-acting agonist of amylin and calcitonin receptors in late phase trials for obesity. Here, authors present structures of cagilintide with each target receptor, revealing the molecular basis for its non-selective action.

    • Jianjun Cao
    • Matthew J. Belousoff
    • Patrick M. Sexton
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Bacterial autotransporters are folded in a process that entraps segments of their N-terminal passenger domain. Here, Leyton et al. identify glycine-aromatic mortise and tenon motifs that mediate the passenger domain’s translocation to the bacterial cell surface, and show that the motifs are evolutionarily conserved.

    • Denisse L. Leyton
    • Matthew D. Johnson
    • Trevor Lithgow
    Research
    Nature Communications
    Volume: 5, P: 1-11

  • X-ray crystallography and cryo-electron microscopy structures of the transcriptional repressor of the methylomycin gene cluster, MmfR, reveal the molecular basis for regulation of antibiotic biosynthesis by AHFCA hormones in Actinobacteria.

    • Shanshan Zhou
    • Hussain Bhukya
    • Christophe Corre
    Research
    Nature
    Volume: 590, P: 463-467

  • The glucagon-like peptide-1 receptor (GLP-1R) can be targeted in the treatment of diabetes, obesity and other metabolic disorders. Here, the authors assess the molecular mechanisms of peptide agonists binding to GLP-1R and the responses elucidated by these ligands, including distinct kinetics of G protein activation.

    • Giuseppe Deganutti
    • Yi-Lynn Liang
    • Denise Wootten
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18

  • Structural and biochemical studies of the Mycobacterium smegmatis hydrogenase Huc provides insights into how [NiFe] hydrogenases oxidize trace amounts of atmospheric hydrogen and transfer the electrons liberated via quinone transport.

    • Rhys Grinter
    • Ashleigh Kropp
    • Chris Greening
    ResearchOpen Access
    Nature
    Volume: 615, P: 541-547

  • Flagellotropic phages spin down flagella to reach the bacterial surface and must withstand remarkable drag forces. Here authors show how two nested sets of chainmail stabilise the viral head and a beta-hairpin regulates the formation of the robust yet pliable tail, characteristic of siphoviruses.

    • Joshua M. Hardy
    • Rhys A. Dunstan
    • Fasséli Coulibaly
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • Cryo-EM structure and dynamics analysis provides a conformational mechanism for tuning of selectivity between calcitonin and amylin receptors through targeted lipid modification of residues 19–22 within the ‘bypass’ motif of amylin peptides.

    • Jianjun Cao
    • Matthew J. Belousoff
    • Patrick M. Sexton
    Research
    Nature Chemical Biology
    Volume: 20, P: 162-169

  • The class B secretin GPCR (SecR) has broad physiological effects, with target potential for treatment of metabolic and cardiovascular disease. Here, authors present a cryo-EM structure and biochemical studies of secretin binding to the SecR:Gs complex which show that interactions between peptide and receptor were dynamic.

    • Maoqing Dong
    • Giuseppe Deganutti
    • Laurence J. Miller
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17

  • The translocation and assembly module (TAM) is a nanomachine responsible for assembly of proteins into the outer membrane of pathogenic bacteria. Here, Shen et al.use magnetic contrast neutron reflectrometry to visualize movements within the TAM and insertion of a substrate protein into the lipid bilayer.

    • Hsin-Hui Shen
    • Denisse L. Leyton
    • Trevor Lithgow
    Research
    Nature Communications
    Volume: 5, P: 1-10

  • Bacterial secretion systems are key to pathogenesis, as they secrete the many virulence factors needed for host colonization. Bioinformatic and functional analyses have identified a transport and assembly module (TAM) in proteobacteria that may be necessary for biogenesis of the autotransporter family of virulence factors.

    • Joel Selkrig
    • Khedidja Mosbahi
    • Trevor Lithgow
    Research
    Nature Structural & Molecular Biology
    Volume: 19, P: 506-510