Nature Search

Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis

Neuropilin-1 (Nrp1) on regulatory T (T_reg) cells is shown to interact with semaphorin-4a (Sema4a) to promote a program of T_reg-cell stability and survival, in part through PTEN-mediated modulation of Akt signalling; Nrp1-deficient T_reg cells can maintain immune homeostasis but fail to suppress in inflammatory sites, such as tumours, providing an attractive immunotherapeutic target for the treatment of cancers.

Greg M. Delgoffe
Seng-Ryong Woo
Dario A. A. Vignali
Research04 Aug 2013
Nature

Volume: 501, P: 252-256
Revealing COVID-19 transmission in Australia by SARS-CoV-2 genome sequencing and agent-based modeling

The combination of nearly real-time genome sequencing of SARS-CoV-2 in infected patients during the first 10 weeks of COVID-19 containment in Australia and epidemiological modeling is helping in understanding the dynamics of the COVID-19 pandemic and potentially guiding public health decisions.

Rebecca J. Rockett
Alicia Arnott
Vitali Sintchenko
Research09 Jul 2020
Nature Medicine

Volume: 26, P: 1398-1404
Climatic backdrop for Pueblo cultural development in the southwestern United States

Victor J. Polyak
Yemane Asmerom
Matthew S. Lachniet
ResearchOpen Access24 May 2022
Scientific Reports

Volume: 12, P: 1-11
Ryder Glacier in northwest Greenland is shielded from warm Atlantic water by a bathymetric sill

A bathymetric sill in Sherard Osborn Fjord, northwest Greenland shields Ryder Glacier from melting by warm Atlantic water found at the bottom of the fjord, according to high-resolution bathymetric mapping and oceanographic data.

Martin Jakobsson
Larry A. Mayer
June Padman
ResearchOpen Access04 Nov 2020
Communications Earth & Environment

Volume: 1, P: 1-10
A centuries-long delay between a paleo-ice-shelf collapse and grounding-line retreat in the Whales Deep Basin, eastern Ross Sea, Antarctica

Philip J. Bart
Matthew DeCesare
Austin McGlannan
ResearchOpen Access17 Aug 2018
Scientific Reports

Volume: 8, P: 1-9
Peri active site catalysis of proline isomerisation is the molecular basis of allomorphy in β-phosphoglucomutase

A structural study shows that the enzyme βPGM uses an allomorphically controlled switch that accelerates proline isomerisation to alleviate the wastage of valuable metabolites while allowing the organism to react quickly to changes in food supply.

F. Aaron Cruz-Navarrete
Nicola J. Baxter
Jonathan P. Waltho
ResearchOpen Access27 Jul 2024
Communications Biology

Volume: 7, P: 1-14
Analyses of GWAS signal using GRIN identify additional genes contributing to suicidal behavior

Using the software GRIN, GWAS results are refined by reducing false positive genes using biological network topology, allowing users to lower GWAS significance thresholds to identify additional genes associated with complex traits

Kyle A. Sullivan
Matthew Lane
David Kainer
ResearchOpen Access21 Oct 2024
Communications Biology

Volume: 7, P: 1-16
Enzyme stabilisation due to incorporation of a fluorinated non-natural amino acid at the protein surface

Arka Mukhopadhyay
Yiwen Li
Paul A. Dalby
ResearchOpen Access14 Nov 2024
Scientific Reports

Volume: 14, P: 1-14
Structural effects of the highly protective V127 polymorphism on human prion protein

Through X-ray crystallography and NMR, Hosszu et al. show that V127 mutation in the human prion protein induces structural changes, leading to conformational restrictions in key regions of the protein associated with prion disease. These may prevent prion formation and explain this mutation′s profound effect on prion disease.

Laszlo L. P. Hosszu
Rebecca Conners
John Collinge
ResearchOpen Access29 Jul 2020
Communications Biology

Volume: 3, P: 1-12
Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data

James H. R. Farmery
Mike L. Smith
Andy G. Lynch
ResearchOpen Access22 Jan 2018
Scientific Reports

Volume: 8, P: 1-17
High dimensional predictions of suicide risk in 4.2 million US Veterans using ensemble transfer learning

Sayera Dhaubhadel
Kumkum Ganguly
Benjamin H. McMahon
ResearchOpen Access20 Jan 2024
Scientific Reports

Volume: 14, P: 1-19
Serum squamous cell carcinoma antigen as an early indicator of response during therapy of cervical cancer

Stephanie Markovina
Songyan Wang
Perry W Grigsby
ResearchOpen Access07 Nov 2017
British Journal of Cancer

Volume: 118, P: 72-78
Publisher Correction: Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data

James H. R. Farmery
Mike L. Smith
Andy G. Lynch
Amendments and CorrectionsOpen Access03 Sept 2018
Scientific Reports

Volume: 8, P: 1-4

Search

Filter By:

Search

Quick links